脑白质疏松与胰岛素抵抗和单核细胞趋化蛋白-1的关系

目的探讨脑白质疏松患者胰岛素抵抗(IR)与血浆单核细胞趋化蛋白-1(MCP-1)水平的关系。方法选择48例脑白质疏松患者,以30例健康者作为对照组。采用放射免疫法测定两组的空腹血胰岛素(FINS)水平,同时检测空腹血糖(FBG)、血脂,以稳态模型评估法(HOMA)评价胰岛素抵抗(HOMA-IR)。采用ELISA法测定血清MCP-1水平。结果脑白质疏松组的MCP-1水平高于健康对照组(P<0.01);脑白质疏松组FINS、HOMA-IR均高于健康对照组(P<0.01)。相关性分析显示脑白质疏松患者血清MCP-1水平与FPG、TC、LDL-C、血清胰岛素、HOMA-IR呈明显正相关(P<0.01)。结论脑白质疏松患者存在胰岛素抵抗,MCP-1与胰岛素抵抗密切相关。

The relationship between insulin resistance and plasma level of chemoattractant protein-1 in in leukoaraiosis

Objective To investigate the relationship between insulin resistance and plasma level of chemoattractant protein-1(MCP-1) in leukoaraiosis.Methods 48 cases of leukoaraiosis and 30 healthy individuals were selected as the control goups.Fasting serum insulin(FINS) levels were determined by radioimmunoassay in two groups.Fasting blood glucose(FBG),blood lipid were measured and homeostasis model assessment method(HOMA-IR) were calculated as well,and the plasma level of MCP-1 was measured by ELISA method.Results The plasma level of MCP-1 in leukoaraiosis group was higher than that in control group(P<0.05).The levels of FINS and HOMA-IR in leukoaraiosis group were higher than those in control group(P<0.05).Dependability analysis showed plasma level of MCP-1 had positive correlation to levels of FPG,TC,LDL-C,FINS and HOMA-IR.Conclusion Insulin resistance exists in leukoaraiosis and plasma level of MCP-1 may be associated with insulin resistance.