艾司西酞普兰与西酞普兰治疗抑郁症的对照研究

目的评价艾司西酞普兰治疗抑郁症的有效性和安全性。方法选择126例抑郁症患者,试验组63例,口服艾司西酞普兰:1-2周口服10 mg,3-6周剂量可调10-20 mg;对照组63例,口服西酞普兰:1-2周口服20 mg,3-6周剂量可调20-40 mg。疗程6周,以十七项汉密尔顿抑郁量表(HAMD-17)、汉密尔顿焦虑量表(HAMA)和临床总体印象量表(CGI)进行疗效评价;以不良事件、实验室检查和心电图检查等评价安全性。结果共106例患者完成研究,试验组52例,对照组54例。试验组与对照组6周末有效率(82.7%vs 88.9%,P=0.484)、痊愈率(36.5%vs.27.8%,P=0.360),2组差异无统计学意义(P>0.05)。HAMA和CGI的评分在各时间点2组相比差异无统计学意义(P>0.05)。试验组与对照组不良反应发生率(17.5%vs 30.2%,P=0.07)差异无统计学意义。结论艾司西酞普兰治疗抑郁症安全有效,与西酞普兰相当,不良反应较轻。

Escitalopram vs citalopram: a parallel controlled study for depression

Objective To evaluate the efficacy and safety of escitalopram in treatment of depression.MethodsA randomized,double-blind,active drug controlled clinical trial was conducted.One hundred twenty-six patients met with CCMD-3 criteria of depression received 6 weeks treatment with escitalopram(1-2 weeks with oral 10 mg,3-6 weeks with flexible dosages 10-20 mg,n=63) or citalopram(1-2 weeks with oral 20mg,3-6 weeks with flexible dosages 20-40 mg,n=63).The primary clinical efficacy was evaluated with the change in total score of 17-items Hamilton Depression Rating Scale(HAMD-17),HAMA,GCI,and the safety with the reports of adverse events,the result of laboratory or electrocardiography examination,etc.ResultsTotal of 106 patients completed the study,52 in escitalopram group and 54 in citalopram group,with total response rates(82.7% vs 88.9%,P=0.484)and remission rates(36.5% vs 27.8%,P=0.36).There were no significant differences between the two groups(P>0.05) in total response rates,remission rates and the score of the HAMA,GCI at all time points.The incidence of adverse events and drug-related adverse event were well tolerated,with no significant difference in the prevalence between the two groups(17.5% vs 30.2%,P=0.07).ConclusionEscitalopram has similar therapeutic effect to citalopram,and rapid onset,better tolerability.