Application of Akaike's information criterion (AIC) in the evaluation of linear pharmacokinetic equations期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Application of Akaike's information criterion (AIC) in the evaluation of linear pharmacokinetic equations

Authors:	Kiyoshi Yamaoka Terumichi Nakagawa Toyozo Uno

Affiliation:	(1) Faculty of Pharmaceutical Sciences, Kyoto University, 606 Kyoto, Japan

Abstract:	According to linear pharmacokinetics, the time course of plasma concentration of a drug, C_p,is expressed by a sum of exponential functions, C_p=_i=1ⁿa_i $C_p = sumnolimits_{i = 1}^n {a_i e^{ - b_i t} }$ .This article describes a statistical technique to estimate the number of exponential terms, n,for the time course of drug by the application of Akaike's information criterion (AIC). Plasma concentrations of ethoxybenzamide, sulfisoxazole, bishydroxycoumarin, and diazepam measured following bolus intravenous injection were used as clinical examples for this method. Selection of models is compared between the AIC method and an Ftest method at significance levels of 5% and 1%.

Keywords:	linear pharmacokinetic equations number of exponential terms amount of information in the time course Akaike's information criterion (AIC) F test ethoxybenzamide sulfisoxazole bishydroxycoumarin diazepam
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