Phase I study of S-1 and biweekly docetaxel combination chemotherapy for advanced and recurrent gastric cancer |
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| Authors: | Takahashi Ikuo Emi Yasunori Kakeji Yoshihiro Tokunaga Eriko Ushiro Shin Oki Eiji Watanabe Masayuki Baba Hideo Maehara Yoshihiko |
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| Affiliation: | Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan. takahashii@matsuyama.jrc.or.jp |
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| Abstract: | A phase I study of S-1 and biweekly docetaxel (DOC) combination therapy was conducted to determine the maximum tolerated dose (MTD) and pharmacokinetic parameters. Fourteen patients with advanced or recurrent gastric cancer were analyzed. The treatment consisted of S-1 [body surface area (BSA) <1.25 m2:80 mg/day, 1.25
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