Kinetics of colony-forming ability of mouse bone marrow cells after administration of hydrocortisone

The dynamics of the colony-forming and migration capacity of polypotent hematopoietic stem cells in the bone marrow of (CBA×C57BL) F₁ mice was studied after injection of hydrocortisone. The relative number of hematopoietic stem cells in the bone marrow was higher than in the control on the 3rd day after hydrocortisone injection. This increase was maximal on the 5th day after the injection. On the 8th day the number of hematopoietic stem cells was down to normal again.Institute of Clinical and Experimental Medicine, Siberian Branch, Academy of Medical Sciences of USSR, Novosibirsk. (Presented by Academician of the Academy of Medical Sciences of the USSR V. P. Kaznacheev.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 82, No. 9, pp. 1102–1104, September, 1976.