功能性心肌血流指数评价缺血性冠心病可行性分析

目的:运用功能性心肌血流指数(MBFI)评价缺血性冠心病(ICAD)可行性分析.方法:回顾性分析冠心病疑似患者行冠状动脉CT血管成像(CCTA)检查,同期接受有创冠状动脉造影(ICA)及导管法心肌血流储备分数(FFR)检查共81例患者,其中男性43例,女性38例,年龄(59.27±9.09)岁;计算MBFI;以FFR≤...

Feasibility of Evaluating Ischemic Coronary Artery Disease by Functional Myocardial Blood Flow Index

Objectives:To investigate the feasibility of functional myocardial blood flow index(MBFI)to evaluate ischemic coronary artery disease(ICAD).Methods:Data from 81 patients(43 males,mean age:[59.27±9.09]years)with suspected coronary artery disease(CAD)were analyzed retrospectively,patients underwent CCTA,ICA,and FFR examinations within 1 week.MBFI was calculated.Using FFR≤0.80 as the gold standard,after the optimal cut-off value was got with the diagnostic test,the diagnostic performance of MBFI and ICA was compared for ischemic CAD.The ROC curve characteristics and diagnostic accuracy of MBFI and ICA were evaluated.Results:In the 81 cases,the average scan dose of CCTA was(3.06±1.22)mSv.There were 25 cases with FFR≤0.80.The optimal cut-off value of MBFI and ICA was 0.074 and 70%,respectively.The area under the curve(AUC)of MBFI and ICA was 0.825 and 0.699(z=2.024,P=0.0429),respectively.The sensitivity,specificity,positive predictive value and negative predictive value of MBFI and ICA were 88.00%,80.35%,66.67%,93.75%and 76.00%,51.79%,41.30%,82.86%,respectively.The diagnostic accuracy was 82.72%,59.26%(χ2=10.753,P<0.01).There were 33 cases(40.74%,33/81)with the ICA stenosis of 65%or 70%,27 out of 33 cases(81.82%,27/33)with FFR>0.80 were free from myocardial ischemia,and non-ischemia could be defined by MBFI>0.074 in 23 cases(69.70%,23/33).Conclusions:MBFI is a functional index,which can be used to detect myocardial ischemia in patients with CAD.