中药注射液治疗慢性肾功能不全的贝叶斯网状Meta分析

采用网状Meta分析方法,以西医常规治疗为共同参照,对比红花注射液、丹参注射液、肾康注射液、疏血通注射液、路路通注射液、参芎葡萄糖注射液、川芎注射液对慢性肾功能不全的临床疗效.计算机检索有关红花注射液、丹参注射液、肾康注射液、疏血通注射液、路路通注射液、参芎葡萄糖注射液、川芎注射液治疗慢性肾功能不全的随机对照试验.由2...

Bayesian network Meta-analysis of Chinese medicine injections in treatment of chronic renal insufficiency

In this study,Honghua Injection,Danshen Injection,Shenkang Injection,Shuxuetong Injection,Lulutong Injection,Shenxiong Glucose Injection and Chuanxiong Injection were compared for their clinical efficacy on chronic renal insufficiency by using the method of network Meta-analysis,with Western medicine as the common reference.The randomized controlled trial(RCT)of Hong-hua Injection,Danshen Injection,Shenkang Injection,Shuxuetong Injection,Lulutong Injection,Shenxiong Glucose Injection and Chuanxiong Injection for the treatment of chronic renal insufficiency were obtained by computer-based retrieval.The literature quality was evaluated by using the method in Cochrane Reviewer′s Handbook 5.1 after independent screening of the included literature by two reviewers.The RJAGS package and GEMTC package of RevMan 5.3,GEMTC software,R software were used for statistical analysis to compare and sort the different injections in terms of efficacy.A total of 6197 patients with chronic renal failure were included in 79 RCTs,involving 8 treatment measures.The effective rates of conventional treatment combined with Shenxiong Injection(OR=3.55,95%CI[1.98,6.37],P<0.0001),Honghua Injection(OR=3.77,95%CI[2.45,5.81],P<0.00001),Shuxuetong Injection(OR=6.71,95%CI[3.30,13.65],P<0.00001)and Shenkang Injection(OR=4.14,95%CI[3.42,5.03],P<0.00001)were all better than that in control group,and the effective rate of Honghua Injection combined with conventional treatment(OR=3.89,95%CI[1.73,8.74],P=0.001)was better than that in Danshen Injection combined with conventional treatment,all with statistically significant differences.By comprehensive comparison,Shuxuetong Injection,Honghua Injection and Shenkang Injection combined with Western medicine had good clinical effect on the effective rate,serum creatinine reduction and urea nitrogen reduction in patients with chronic renal insufficiency.However,due to the relatively low quality of the included literature,the conclusion has yet to be verified clinically.