Two new lanostanoids from Ganoderma resinaceum |
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Authors: | Niu Xue-Mei Li Sheng-Hong Xiao Wei-Lie Sun Han-Dong Che Chun-Tao |
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Institution: | School of Chinese Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China. |
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Abstract: | Two new lanostane triterpenoids, 3-epipachymic acid (3alpha-acetoxy-16alpha-hydroxy-24-methylene-5alpha-lanost-8-en-21-oic acid, 1) and 3alpha-(3-hydroxy-5-methoxy-3-methyl-1,5-dioxopentyloxy)-24-methylene-5alpha-lanost-8-en-21-oic acid (2), together with a known compound, 3-oxo-5alpha-lanosta-8,24-dien-21-oic acid (3), were isolated from the fruiting body of Ganoderma resinaceum. The structure elucidation was accomplished by spectroscopic methods, especially NMR experiments. Compound 2 showed significant cytotoxic activity with IC(50) value of 2.5 microg/ml in Hep-2 cell line. |
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