内消片对试验大鼠前列腺增生的影响

目的:探讨内消片对大鼠前列腺增生模型的影响.方法:大鼠去睾丸1周后,皮下注射丙酸睾酮(5mg/kg)建立大鼠前列腺增生模型,同时连续灌胃内消片大、中、小剂量组(3.0g/kg,1.5g/kg,0.75g/kg)4周,末次给药1h后处死动物,取前列腺称重量,计算前列腺指数(PI)并在光镜下进行病理学观察.结果:给药4周后非那雄胺组、内消片高剂量组与模型组PI比较,P＜0.01;非那雄胺组与内消片高剂量组PI比较,P＞0.05.结论:内消片对大鼠前列腺增生的进展有抑制作用,其作用与非那雄胺相当.

Therapeutic efficacy of Neixiao tablets on prostate gland hyperplasia in rats

Objective: To investigate the therapeutic efficacy of Neixiao tablets on the rat model of prostate gland hyperplasia.Methods: Rats were subcutaneously injected with testosterone propionate(5mg/kg) 1 week after testis removal to establish a rat model of prostate gland hyperplasia.Some of the rats were divided into high-dose,medium-dose,and low-dose Neixiao tablet groups and finasteride group to receive intragastric administration of Neixiao tablets(3.0g/kg,1.5g/kg,or 0.75 g/kg) and finasteride for 4 weeks.The other rats were assigned to model group.The rats were killed 1 h after the last administration,and the prostate gland was weighed to calculate prostate index(PI) and was observed under light microscope.Results: The finasteride group and high-dose Neixiao tablet group showed significantly higher PI than the model group after 4 weeks of treatment(P<0.01).There was no significant difference in PI between the finasteride group and high-dose Neixiao tablet groups(P>0.05).Conclusion: Neixiao tablets can inhibit progression of prostate gland hyperplasia,exhibiting a comparable effect as finasteride.