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| 蟾蜍干预对大鼠肾病模型CD2AP表达的影响 | |
| 引用本文： | 林丽,杨树升,朱黎明,钟飞. 蟾蜍干预对大鼠肾病模型CD2AP表达的影响[J]. 医学信息, 2006, 19(5): 837-839 |
| 作者姓名： | 林丽 杨树升 朱黎明 钟飞 |
| 作者单位： | 吉首大学医学院,湖南吉首416000 |
| 摘 要： | 目的 探讨CD2-associated protein（CD2AP）在蟾蜍干预阿霉素肾病模型肾小球中的表达及意义。方法 通过建立阿霉素（ADR）肾病模型，用蟾蜍等干预后，采用免疫组织化学技术观察各组模型大鼠肾小球中CD2AP的表达变化。结果 蟾蜍能使肾小球足细胞CD2AP的表达上调。结论 蟾蜍对肾病大鼠模型病理损伤的修复可能与CD2AP表达上调有关。 |
| 关 键 词： | 微小病变肾病模型 蟾蜍 足细胞 CD2相关蛋白 免疫组织化学 |
| 收稿时间： | 2005-12-01 |
| 修稿时间： | 2006-01-09 |
The effect of CD2AP expression on rats with adriamycin nephrosis intervented by toad |
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| LIN Li,YANG Shu-sheng,ZHU Li-ming,ZHONG Fei. The effect of CD2AP expression on rats with adriamycin nephrosis intervented by toad[J]. Medical Information, 2006, 19(5): 837-839 | |
| Authors: | LIN Li YANG Shu-sheng ZHU Li-ming ZHONG Fei |
| Affiliation: | Medical college of Jishou university, Jishou 41600, China |
| Abstract: | Objective To investigate the role of CD2-associated protein(CD2AP) in the pathogensis of adrimycin nephrosis in rats treated with toad and so on. Methods A minimal change nephropathy model that is similar to humans was induced by adriamycin(ADR) in rats. The rats were randomly divided into five groups: normal control, nephritic control, the groups treated with toad, prednisone or toads and prednisone. Renal tissues were studied by means of immunohistochemistry. Results CD2AP expression was in association with an increasing in the group treated with toad. Conclusion This result suggests that toad plerosis the regain of renal lesion in NS rats through up-regulating the expression of CD2AP. |
| Keywords: | Minimal change nephropathy model Toad Podocyte CD2-associated protein immunohistochemistry |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |