| Cocktail探针药物评价姜黄对肝细胞色素P_(450)酶的影响 |
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| 引用本文： | 扈金萍,闫淑莲,唐静成,张锦楠.Cocktail探针药物评价姜黄对肝细胞色素P_(450)酶的影响[J].首都医学院学报,2004,25(4):427-430. |
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| 作者姓名： | 扈金萍 闫淑莲 唐静成 张锦楠 |
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| 作者单位： | 首都医科大学基础医学院化学药理系
(扈金萍，闫淑莲，唐静成)，首都医科大学基础医学院化学药理系(张锦楠) |
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| 基金项目： | 北京市教委科技基金 (KM 2 0 0 410 0 2 5 0 0 7)资助项目 |
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| 摘 要： | 用Cocktail探针药物法 ,研究姜黄对大鼠肝细胞P4 50 (CYP4 50 )的影响。将SD雄性大鼠分组 ,给予姜黄的水提物 ,以生理盐水组为空白对照 ,以苯巴比妥组为阳性对照 ,通过HPLC检测Cocktail探针药物的代谢率来评价各组的CYP4 50 。结果 :给予姜黄组的大鼠CYP1A2和CYP2E1的水平显著低于对照组 ,CYP3A4的水平没有显著变化。表明 :姜黄对大鼠CYP1A2和CYP2E1有抑制作用 ,但对大鼠CYP3A4的影响不显著。
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| 关 键 词： | Cocktail CYP450 咖啡因 氨苯砜 氯唑沙宗 探针药物 姜黄 |
| 收稿时间： | 2003-08-20 |
| 修稿时间： | 2003年8月20日 |
Simultaneous Evaluation of Effect of Rhizoma Curcumae Longae on Hepatic CYP450 by Cocktail Probe Drugs |
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| Hu Jinping,Yan Shulian,Tang Jingcheng,Zhang Jinnan.Simultaneous Evaluation of Effect of Rhizoma Curcumae Longae on Hepatic CYP450 by Cocktail Probe Drugs[J].Journal of Capital University of Medical Sciences,2004,25(4):427-430. |
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| Authors: | Hu Jinping Yan Shulian Tang Jingcheng Zhang Jinnan |
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| Institution: | Department of Chemical Pharmacology, Capital University of Medical Sciences |
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| Abstract: | The aim was to study the change of the rat hepatic CYP 450 content following administration of Rhizoma Curcumae Longae by cocktail probe drugs. Rats were randomly divided into groups. One group of rats received Rhizoma Curcumae Longae plant extracts once daily orally for six days. The rats in another group received once daily orally normal saline as blank control group and phenobarbital as positive control group at the same time. The plasma concentration of cocktail probe drugs was determined by HPLC. The CYP1A2 and CYP2E1 content of the groups of rats received Rhizoma Curcumae Longae plant extracts was reduced, but the CYP3A4 content didn't markedly change. It suggests that Rhizoma Curcumae Longae is inhibitor of the CYP1A2 and CYP2E1, but the CYP3A4 can be hardly affected. |
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| Keywords: | Cocktail CYP450 caffeine dapsone chlorzoxazone probe drugs Rhizoma Curcumae Longae |
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