| 度洛西汀与艾司西酞普兰治疗老年抑郁症对照研究 |
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| 引用本文： | 高良会,颜景祥,张扬,杨老虎. 度洛西汀与艾司西酞普兰治疗老年抑郁症对照研究[J]. 中国健康心理学杂志, 2011, 19(9): 1029-1030 |
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| 作者姓名： | 高良会 颜景祥 张扬 杨老虎 |
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| 作者单位： | 中国,河北省第六人民医院,保定,071000 |
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| 摘 要： | 目的观察度洛西汀与艾司西酞普兰治疗老年抑郁症的疗效及安全性。方法 64例老年抑郁症患者随机分为度洛西汀组（31例）和艾司西酞普兰组（33例）,治疗剂量分别为30~60m g/d和10~15m g/d,观察6周。用汉密尔顿抑郁量表（HAM D）评定疗效,用不良反应量表（TESS）评估不良反应和安全性。结果治疗第6周末度洛西汀组和艾司西酞普兰组的有效率分别为77%（24/31）和76%（25/33）,差异无统计学意义（χ2=0.10,P〉0.05）;临床痊愈率分别为52%（16/31）和55%（18/33）,差异无统计学意义（2χ=0.25,P〉0.05）。治疗第1周末,度洛西汀组起效率为35%（11/31）,与艾司西酞普兰组36%（12/33）相比差异无统计学意义（2χ=0.14,P〉0.05）。不良反应发生比例大于10%的度洛西汀组为便秘、失眠和食欲降低,艾司西酞普兰组为失眠和疲劳。结论度洛西汀和艾司西酞普兰对老年抑郁症患者同样安全有效。
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| 关 键 词： | 度洛西汀 艾司西酞普兰 抑郁症 老年 |
Comparative Study of Duloxetine versus Escitalopram in the Treatment of Elderly Depression |
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| Gao Lianghui,Yan Jingxiang,Zhang Yang,et al.. Comparative Study of Duloxetine versus Escitalopram in the Treatment of Elderly Depression[J]. china journal of health psychology, 2011, 19(9): 1029-1030 |
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| Authors: | Gao Lianghui Yan Jingxiang Zhang Yang et al. |
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| Affiliation: | Gao Lianghui,Yan Jingxiang,Zhang Yang,et al.Psychiatry Department,Heibei Mental Health Center,Baoding 071000,P.R.China |
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| Abstract: | Objective To observe the efficacy and safety of Duloxetine and Escitalopram in elderly depression.Methods A total of 64 patients with episode depression were randomly divided into Duloxetineg roup(n=31) and Escitalopram group(n=33).The patients were treated with Duloxetine(30~60mg/d) or Escitalopram(10~15mg/d) for 6 weeks.The efficacy was assessed with Hamilton depression rating scale(HAMD 17) and the side effects were assessed with Treatment Emergent Symptoms Scale(TESS).Results The efficacy rates of the D... |
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| Keywords: | Duloxetine Escitalopram Depression Elderly |
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