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| Effects of Mycophenolate Mofetil on Renal Interstitial Fibrosis after Unilateral Ureteral Obstruction in Rats | |
| 引用本文： | 张春,朱忠华,王刚,邓安国. Effects of Mycophenolate Mofetil on Renal Interstitial Fibrosis after Unilateral Ureteral Obstruction in Rats[J]. 华中科技大学学报(医学英德文版), 2003, 23(3): 269-270. DOI: 10.1007/BF02829510 |
| 作者姓名： | 张春 朱忠华 王刚 邓安国 |
| 作者单位： | Department of Nephrology，Department of Nephrology，Department of Nephrology，Department of Nephrology Xiehe Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430022，Xiehe Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430022，Xiehe Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430022，Xiehe Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430022 |
| 基金项目： | ThisprojectwassupportedbyagrantfromtheMedicalFoundationofHubeiHealthBureau (SerialNo :WJ 0 15 30 ) |
| 摘 要： | Theseverityoftubulointerstitialfibrosishaslongbeenconsideredasthecrucialdeterminantinprogres siverenalinjuryandlong term prognosisinbothhu manandexperimentalglomerulonephritis[1] Howtoimpedeinterstitialfibrosisandlimittheprogressionofchronicrenaldiseasestowardsend stagerenaldisease(ESRD)becomeanewfocusinthisfield Mycophenolatemofetil (MMF)isahighlyspe cificimmunosuppressor Interestingly ,MMFisanimmunosuppressivedrugthatisalsoknowntohaveaneffectoncellsoutsideimmunesystemandparticu larlyhav… |
| 收稿时间： | 2001-11-08 |
Effects of mycophenolate mofetil on renal interstitial fibrosis after unilateral ureteral obstruction in rats |
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| Zhang Chun,Zhu Zhonghua,Wang Gang,Deng Anguo. Effects of mycophenolate mofetil on renal interstitial fibrosis after unilateral ureteral obstruction in rats[J]. Journal of Huazhong University of Science and Technology. Medical sciences, 2003, 23(3): 269-270. DOI: 10.1007/BF02829510 | |
| Authors: | Zhang Chun Zhu Zhonghua Wang Gang Deng Anguo |
| Affiliation: | Department of Nephrology , Xiehe Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan 430022 |
| Abstract: | Summary To investigate the effects of mycophenolate mofetil (MMF) on the process of renal interstitial fibrosis, unilateral ureteral obstruction (UUO) model was established in rats. Twenty Sprague-Dawley rats underwent UUO and received vehicle (n=10) or MMF (20 mg. kg−1, d−1, by daily gastric gavage,n=10) during a period of 5 days following surgery, and the additional 10 rats were served as sham-operated group. The rats were killed 5 days after surgery. Immunohistochemistry was performed on renal tissue for proliferating cell nuclear antigen (PCNA), α-smooth muscle actin (α-SMA) and type I and III collagen (col I, col III). Histological studies were also done by MASSON staining. Five days after surgery, proliferating cells in tubules, interstitium as well as interstitial myofibroblast (MyoF) infiltration and interstitial col I, col III deposition were all significantly reduced by MMF treatment. MMF also alleviated the histological changes of UUO rats. These results suggested that the reduction of interstitial MyoF infiltration may be an important event by which MMF prevents renal injury caused by UUO and MMF could be used to limit the progression of renal fibrosis. ZHANG Chun, male, born in 1977, M.D. Ph.D. Candidate This project was supported by a grant from the Medical Foundation of Hubei Health Bureau (Serial No: WJ 01530). |
| Keywords: | fibrosis renal interstitium mycophenolate mofetil |
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