| The Expression of PLF in Placenta in Pregnancy-Induced Hypertension and the Relationship between the PLF and Serum VCAM-1 |
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| 作者姓名： | 徐晓燕 相文佩 陈汉平 |
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| 作者单位： | Department of Obstetrics and Gynecology，Tongji Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430030，Department of Obstetrics and Gynecology，Tongji Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430030，Department of Obstetrics and Gynecology，Tongji Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430030 |
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| 摘 要： | Summary:To study the expression of placental isoferritin(PLF)in placental tissue of pregnancy-in-duced hypertension(PIH)and the relationship between the level of expression of PLF and theamount of vascular cell adhesion molecule-1(VCAM-1)in serum,immunohistochemical techniquewas used to detect the expression of PLF in placenta tissue in 45 PIH patients(PIH group)and 15normal pregnant women(normal group).High resolution pathological image analysis system(HPIAS-100)was employed to determine the quantity of PLF.The VCAM-1 in serum was exam-ined by enzyme linked immunoabsorbent assay(ELISA).The results showed that the levels of PLFexpressions in moderate and severe PIH patients were significantly lower than that of normal group(P<0.01).The serum VCAM-1 was significantly decreased in PIH group(1310±177ρ/mg/ml)than that of normal group(609±72ρ/ng/ml,P<0.01).The significant negative correlation exist-ed betweene the expression of PLF in placental tissue and the serum VACM-1(r=0.58,P<0.01).It was concluded
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| 收稿时间： | 28 February 2003 |
The expression of PLF in placenta in pregnancy-induced hypertension and the relationship between the PLF and serum VCAM-1 |
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| Xu Xiaoyan,Xiang Wenpei,Chen Hanping.The Expression of PLF in Placenta in Pregnancy-Induced Hypertension and the Relationship between the PLF and Serum VCAM-1[J].Journal of Zuazhong University of Science and Technology: Medical Edition,2003,23(2):184-186. |
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| Authors: | Xu Xiaoyan Xiang Wenpei Chen Hanping |
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| Institution: | Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical college of Huazhong University of Science and Technology, Wuhan 430030 |
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| Abstract: | Summary To study the expression of placental isoferritin (PLF) in placental tissue of pregnancy-induced hypertension (PIH) and the
relationship between the level of expression of PLF and the amount of vascular cell adhesion molecule-1 (VCAM-1) in serum,
immunohistochemical technique was used to detect the expression of PLF in placenta tissue in 45 PIH patients (PIH group) and
15 normal pregnant women (normal group). High resolution pathological image analysis system (HPIAS-100) was employed to determine
the quantity of PLF. The VCAM-1 in serum was examined by enzyme linked immunoabsorbent assay (ELISA). The results showed that
the levels of PLF expressions in moderate and severe PIH patients were significantly lower than that of normal group (P<0.01). The serum VCAM-1 was significantly decreased in PIH group (1310±177 ρ/ng/ml) than that of normal group (609±72 ρ/ng/ml,P<0.01). The significant negative correlation existed between the expression of PLF in placental tissue and the serum VACM-1
(r=0.58,P<0.01). It was concluded that the level of PLF expression in PIH decreases and is negatively correlated with the mount of
serum VCAM-1, indicating that these may be involved in the pathogenesis of PIH.
XU Xiaoyan, female, born in 1975, Postgraduate Student |
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| Keywords: | pregnancy-induced hypertension placenta ferritin cell adhesion molecules |
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