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| Expression of Angiogenic Factors in Hepatocellular Carcinoma after Transcatheter Arterial Chemoembolization | |
| 引用本文： | 廖晓锋,易继林,李兴睿,杨志芳,邓巍,田耕. Expression of Angiogenic Factors in Hepatocellular Carcinoma after Transcatheter Arterial Chemoembolization[J]. 华中科技大学学报(医学英德文版), 2003, 23(3): 280-282. DOI: 10.1007/BF02829514 |
| 作者姓名： | 廖晓锋 易继林 李兴睿 杨志芳 邓巍 田耕 |
| 作者单位： | Department of General Surgery，Department of General Surgery，Department of General Surgery，Department of General Surgery，Department of General Surgery，Department of General Surgery Tongji Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430030，Tongji Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430030，Tongji Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430030，Tongji Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430030，Tongji Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430030，Tongji Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430030 |
| 摘 要： | We previouslyreportedthatthemicrovesseldensity (MVD)inresidualhepatocellularcarcinoma(HCC)wassignificantlyincreasedafterundergoingtranscatheterarterialchemoembolization (TACE) [1] ,andhypothesizedthattumorangiogenesisafterTACEmightberelatedtoabnormalexpressionofsomean giogenicfactors Therefore ,weexaminedtheexpres sionofvascularendothelialgrowthfactor (VEGF )andbasicfibroblastgrowthfactor (bFGF )byim munohistochemistryinliversamplesfromHCC pa tientswhohadundergonehepatectomyfollowingT… |
| 收稿时间： | 2002-10-28 |
Expression of angiogenic factors in hepatocellular carcinoma after transcatheter arterial chemoembolization |
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| Liao Xiaofeng,Yi Jilin,Li Xingrui,Yang Zhifang,Deng Wei,Tian Geng. Expression of angiogenic factors in hepatocellular carcinoma after transcatheter arterial chemoembolization[J]. Journal of Huazhong University of Science and Technology. Medical sciences, 2003, 23(3): 280-282. DOI: 10.1007/BF02829514 | |
| Authors: | Liao Xiaofeng Yi Jilin Li Xingrui Yang Zhifang Deng Wei Tian Geng |
| Affiliation: | Department of General Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030 |
| Abstract: | Summary In order to investigate the changes of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) expression in residual hepatocellular carcinoma (HCC) after transcatheter arterial chemoembolization (TACE), the expression levels of VEGF and bFGF expression in specimens surgically removed from 48 HCC patients were detected by immunohistochemical methods, and staining intensity of VEGF and bFGF was assessed by a computer-assisted image-analyzer. Among the 48 patients, 25 underwent partial hepatectomy alone (single operating group), and 23 were subjected to second stage surgical resection after TACE (TACE group). The results showed that the average absorbance value (A) of VEGF was higher in TACE group than that in single operating group (0.152±0.021 vs 0.131±0.012,P<0.01). The Average A of bFGF in TACE group was 0.127±0.023, higher than in single operating group (0.111±0.016,P<0.05). These results suggested that TACE of HCC can up-regulate the expression of VEGF and bFGF in HCC tissues possibly due to anoxia and ischemia. LIAO Xiaofeng, male, born in 1966, M.D., Ph.D., Associate Professor |
| Keywords: | hepatocellular carcinoma chemoembolization vascular endothelial growth factor basic fibroblast growth factor |
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