| A Comparative Study on the Effect of BCG-PSN and Thymopeptides on T-lymphocyte Subsets of Normal and Immunosuppressed Mice |
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| 作者姓名： | 邓云华 陈映玲 陈兴平 李永喜 周礼义 |
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| 作者单位： | Department of Dermatology，Department of Dermatology，Department of Dermatology，Department of Dermatology，Department of Dermatology Tongji Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430030，Tongji Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430030，Tongji Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430030，Tongji Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430030，Tongji Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430030 |
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| 摘 要： | Polysaccharidenucleicacidfractionofbacilluscalmetteguerin (BCG PSN ,SiqikangInjection)andthymopeptidesarenowtwowidelyusedimmunomod ulatorsinclinicalpractice .Theyareusuallyusedasanadjuvanttherapyforvirusinfection ,autoimmunediseasesandneoplasms ,whichhavebeenclinicallyprovedtobeeffective .Somereportsdemonstratedthattheybothcanstimulatetheproliferationanddif ferentiationofT lymphocytes.However ,theexactmechanismshavenotbeenelucidatedyet .InordertocomparetheirmodulatingmechanismsonT lympho c…
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| 收稿时间： | 25 September 2001 |
A comparative study on the effect of BCG-PSN and thymopeptides on T-lymphocyte subsets of normal and immunosuppressed mice |
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| Deng Yunhua,Chen Yingling,Chen Xingping,Li Yongxi,Zhou Liyi.A Comparative Study on the Effect of BCG-PSN and Thymopeptides on T-lymphocyte Subsets of Normal and Immunosuppressed Mice[J].Journal of Zuazhong University of Science and Technology: Medical Edition,2003,23(4):339-343. |
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| Authors: | Deng Yunhua Chen Yingling Chen Xingping Li Yongxi Zhou Liyi |
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| Institution: | Department of Dermatology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030 |
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| Abstract: | To compare the effects of polysaccharide nucleic acid fraction of bacillus calmette guerin (BCG PSN) and thymopeptides on T lymphocytes of normal and immunosuppressed mice, CD4 + and CD8 + T lymphocyte subsets of single nucleic cell in thymus, spleen and peripheral blood were detected successively by flow cytometry after application of BCG PSN and thymopeptides. Meanwhile, CD4 +/CD8 + ratio was also calculated. The results showed that both BCG PSN and thymopeptides could decrease the proportion of CD4 + CD8 + T lymphocyte subsets in the thymus, at the same time increase CD4 + T lymphocyte, CD8 +T lymphocyte proportion in the three tissues. The fluctuation in amplitude was greater in thymopeptides group than that in BCG PSN group. It is concluded that acting location of thymopeptides is in thymus, its stimulating action is stronger than that of BCG PSN, while BCG PSN not only accelerates the differentiation in thymus, but also has some direct stimulation to peripheral CD4 +T lymphocytes, and can maintain CD4 +/CD8 + ratio within normal range. So, BCG PSN is safer. |
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| Keywords: | polysaccharide nucleic acid fraction of bacillus calmette guerin thymopeptides T-lymphocyte CD4 +/CD8 + ratio CD4 + T-lymphocyte CD8 + T-lymphocyte |
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