| 天山花楸水提取液药理学研究 |
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| 引用本文： | 李迪民,陈坚.天山花楸水提取液药理学研究[J].中草药,1995(6):302-304. |
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| 作者姓名： | 李迪民 陈坚 |
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| 作者单位： | 新疆医学院药理教研室!乌鲁木齐830054 |
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| 基金项目： | 新疆维吾尔自治区教委科研基金 |
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| 摘 要： | 天山花楸水提取液民间用以治疗咳嗽、痰症、哮喘等有效。本文实验表明，天山花楸水提取液具有对抗氨水引起小鼠咳嗽的作用，有明显的祛痰作用和对抗乙酰胆碱－组织胺混合液引起的药物性哮喘。天山花楸水提取液还可减慢心率。延长小鼠心电图的P－R间期。离体兔心房实验，发现其可剂量依赖性地抑制心肌收缩力。与一般平喘药不同，它对心肌产生抑制作用，这是其一个特点。
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| 关 键 词： | 天山花楸 止咳 祛痰 平喘作用 负性肌力 |
| 收稿时间： | 1994/6/27 0:00:00 |
Studies on the Pharmacology of Extracts of Tianshan Mountain Mountainash (Sorbus tianschanica) |
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| Li Dimin and Chen Jian.Studies on the Pharmacology of Extracts of Tianshan Mountain Mountainash (Sorbus tianschanica)[J].Chinese Traditional and Herbal Drugs,1995(6):302-304. |
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| Authors: | Li Dimin and Chen Jian |
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| Institution: | Department of Pharmacology, Xinjian Medicinal College, Wulumuqi;Department of Pharmacology, Xinjian Medicinal College, Wulumuqi |
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| Abstract: | It has got good effects that aqueous extracts of Sorbus tianschonica Rupr (AQ-ESTR) used for the treatment of chronic bronchitis, Pulmonary tuberculosis and edema etc in folk medicine. The pharmacological experiment showed that AQESTR had antibechic effect on mice induced by ammonia water, expectorant effect and antiasthmic effect on guinea pig induced by mixture of Ach-histamine. Cardiac Pharmacological experiment also showed AQESTR Produced significant bridycardia in mice. At the dose of 25mg/kg, AQESTR decreascd the heart rate and Prolonged the P-r interval of ECG in vivo, AQESTR decreased the contractive force of isolated atrial muscles rabbits in dose-dependent manner. |
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