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Strong anti-mutagenic activity of the novel lipophilic antioxidant 1-O-hexyl-2,3,5-trimethylhydroquinone against heterocyclic amine-induced mutagenesis in the Ames assay and its effect on metabolic activation of 2-Amino-6-methyldipyrido[1,2-a:3', 2'-d]imidazole (Glu-P-1) |
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| Authors: | Hirose, Masao Iwata, Shinjiro Ito, Eiji Nihro, Yasunori Takahashi, Satoru Mizoguchi, Yasumoto Miki, Tokutaro Satoh, Toshio Ito, Nobuyuki Shirai, Tomoyuki |
| Affiliation: | First Department of Pathology, Nagoya City University, Medical School 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467 1Nippon Hypox Laboratory Inc. 9420 Nanbu, Nanbu-cho, Minamikoma-gun, Yamanashi 409-22 2Faculty of Pharmaceutical Sciences, Tokushima Bunri University Yamashiro-cho, Tokushima 770, Japan |
| Abstract: | Antimutagenic effects of a novel lipophilic antioxidant, 1-O-hexyl-2,3,5-trimethylhydroquinone(HTHQ), and other known antioxidants against heterocyclic amine-or other mutagen-induced mutagenesis were examined in the Amesassay using Salmonella strain TA 98 to access the chemopreventiveeffects of antioxidants on heterocyclic amineinduced carcinogenesis.Further the mechanisms of inhibition by HTHQ were accessed.HTHQ was shown to potently inhibit mutagenesis induced by allof 8 different heterocyclic amines at rates between 100% and63% in the presence of S9 mix. When the protection of HTHQ against2-amino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole (Glu-P-1)-inducedmutagenesis was compared with known antioxidants t-butylhydroquinone,propyl gallate, BHA, BHT and |
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