腹腔液及血液性激素测定在未破裂卵泡黄素化综合征诊断中的意义

应用腹腔镜检抽吸40例不孕症妇女腹腔液,测定其17β-雌二醇(E_2)孕酮(P)并与血液中E_2、P含量进行比较分析。结果显示在黄体早期,腹腔液中E_2、P浓度较血液中高5～10倍并持续6天。镜下见及末见排卵斑周期腹腔液中E_2、P浓度差异有极显著意义。以腹腔液E_2≥68.12pmol/L和P≥11.08nmol/L为排卵标准,诊断未破裂卵泡黄素化综合征(LUFS)15例(占38%)。以腹腔液E_2和P与同期血液E_2、P浓度比值≥5,诊断LUFS12例,(占30%),两种方法诊断符合率为80%。认为腹腔镜检同时测定腹腔液与血液中E_2、P浓度、结合子宫内膜病检是目前诊断LUFS较实用和可靠的方法。

Steroid hormone assays of peritoneal fluid and plasma: a diagnostic measure of the luteinized unruptured follicle syndrome

In 40 women with infertility peritoneal fluid (PF)was aspirated under laparoscopy and levels of steroid hormones in PF and in plasma were measured. During early luteal phase,the PF 17beta-oestradiol(E_2) and progesterone (P)concertrations were approximately 5～10 times higher than those in plasma,respectively, which lasted for 6 days. The steroid hormone concertrations in PF were significantly higher in women with a detected stigma under laparoscopy than without stigma. The concertrations of E_2≥68.12pmol/L and P≥ll.18nmol/L in PF, were seen in 88% of women with stigma, whereas in those without stigma only 9% and 26% showed such concertrations. According to these criteria in the accuracies diagnosis of ovulation or luteinized unruptured follicle syndrome (LUFS) were 62% and 38% respectively. The concertrations of E_2 and P in PF were five times higher than serum concertrations in 70% normal women,30% LUFS women. The accuracy in diagnosis of LUFS by these two methods was 80%. In conclution, the measurement of E_2 and P in PF and in plasma is an effective method in LUFS diagnosis.