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| 三硝基甲苯血红蛋白加合物与接触量的关系 | |
| 引用本文： | 宋文佳,王雅文,闫慧芳,冷曙光,谷也平,刘玉瑛,郑玉新. 三硝基甲苯血红蛋白加合物与接触量的关系[J]. 中华劳动卫生职业病杂志, 2002, 20(3): 189-191 |
| 作者姓名： | 宋文佳 王雅文 闫慧芳 冷曙光 谷也平 刘玉瑛 郑玉新 |
| 作者单位： | 中国预防医学科学院劳动卫生与职业病研究所毒理学研究室,北京,100050 |
| 基金项目： | 欧盟合作课题(ERB3514PL961376) |
| 摘 要： | 目的：探讨反映三硝基甲苯（TNT）接触水平的生物标志物，研究TNT作业工人体内的血红蛋白加合物与接触量的关系。方法：使用GC－MS法测定25名TNT作业工人血液中TNT血红蛋白加合物（4A－Hb、2A－Hb）的含量，观察其与接触量的相关性。接触水平以空气污染量和皮肤污染量表示。结果：血红蛋白加合物4A－Hb、2A－Hb与总接触水平相关，尤其与皮肤接触量相关性更强；其中4A－Hb与总接触水平的回归曲线和血红蛋白加合物总量（4A－Hb 2A-Hb)与总接触水平的回归曲线的斜率（F＝0．03）及截距（F＝0．11）的差异均无显著性（P＞0．05）。结论：血红蛋白加合物4A-Hb、2A－Hb均可用于评价TNT总接触水平，其中4A－Hb更适宜评价TNT的接触水平。 |
| 关 键 词： | 三硝基甲苯 血红蛋白加合物 接触剂量 职业危害 |
| 修稿时间： | 2001-12-26 |
The relationship between hemoglobin adducts of trinitrotoluene and exposed level |
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| SONG Wenjia,WANG Yawen,YAN Huifang,LENG Shuguang,GU Yeping,LIU Yuying,ZHENG Yuxin. The relationship between hemoglobin adducts of trinitrotoluene and exposed level[J]. Chinese journal of industrial hygiene and occupational diseases, 2002, 20(3): 189-191 | |
| Authors: | SONG Wenjia WANG Yawen YAN Huifang LENG Shuguang GU Yeping LIU Yuying ZHENG Yuxin |
| Affiliation: | Institute of Occupational Health, Chinese Academy of Preventive Medicine, Beijing 100050, China. |
| Abstract: | Objective To explore the biomarkers for monitoring trinitrotoluene(TNT)exposure,the rela-tionship between TNT hemoglobin adducts and TNT exposed level.Method Hemoglobin adducts(4A-Hb and2A-Hb )were determined by GC-MS in25TNT exposed workers.TNT exposed level was evaluated by determin-ing skin contaminated and inhaled TNT levels.The correlation between hemoglobin adducts level and TNT exposed level was analyzed.Results There was a correlation between total TNT exposure level,especially skin exposure level,and4A-Hb or2A-Hb content.No significant difference was found between the slopes and intercepts of lin ear equation of(4A-Hb )vs TNT exposed level and linear equation of(4A-Hb +2A-Hb )vs TNT exposed level(P>0.05).Con clu sion Skin contamination is the major role of TNT exposure.TNT exposed level can be evalu-ated by determining the content of both4A-Hb and2A-Hb ,and4A-Hb is more suitable for monitoring TNT expo-sure.[ |
| Keywords: | Trinitrotoluene Exposed level Hemoglobin adducts |
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