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| 河南省乙型肝炎病毒基因型的分布 | |
| 引用本文： | 邹祺,张善锋,毛红丽. 河南省乙型肝炎病毒基因型的分布[J]. 郑州大学学报(医学版), 2006, 41(5): 941-942 |
| 作者姓名： | 邹祺 张善锋 毛红丽 |
| 作者单位： | 郑州大学护理学院基础教研室,郑州,450052;郑州大学基础医学院生物化学与分子生物学教研室,郑州,450052;郑州大学第一附属医院检验科,郑州,450052 |
| 摘 要： | 目的:研究河南省乙型肝炎病毒基因型的分布.方法:随机选择HBV表面抗原携带者76例,慢性乙型肝炎患者80例,应用PCR方法检测血清HBV DNA含量,采用微板核酸杂交-ELISA技术进行血清HBV基因分型.结果:HBV携带者76例中,43例HBV DNA定量阳性;慢性乙型肝炎患者80例,HBV DNA定量均为阳性.HBV DNA定量阳性的123例中,B型65例(52.85%),C型38例(30.89%),B、C混合型5例(4.07%),B、D混合型3例(2.44%),C、D混合型4例(3.25%),未分型者8例.结论:河南省乙型肝炎病毒基因型以B、C型为主. |
| 关 键 词： | 乙型肝炎病毒 基因型 分布 |
| 收稿时间： | 2006-01-23 |
| 修稿时间： | 2006-01-23 |
Distribution of HBV genotype in Henan province |
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| ZOU Qi,ZHANG Shanfeng,MAO Hongli. Distribution of HBV genotype in Henan province[J]. Journal of Zhengzhou University: Med Sci, 2006, 41(5): 941-942 | |
| Authors: | ZOU Qi ZHANG Shanfeng MAO Hongli |
| Affiliation: | 1 . Nursing College, Zhengzhou University, Zhengzhou 450052; 2 . Department of Human Anatomy, College of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450052; 3. Department of Clinical Laboratory, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052 |
| Abstract: | Aim: To study the genotype distribution of HBV in Henan province.Methods:A total of 76 HBV carriers and 80 chronic HBV patients were subjected to measure HBV DNA in serum using FQ-PCR. Micro-PCR and hybridization were used to determine the genotype.Results: HBV-DNA were positive in 43 out of 76 HBV carries and all (80) the patients. In the 123 cases, type B accounted for 52.85% (65 cases), type C accounted for 30.89% (38 cases), mixed type C and D accounted for 3.25% (4 cases), mixed type B and C accounted for 4.07% (5 cases), and mixed type B and D accounted for 2.44% (2 cases). Eight samples were not grouped. Conclusion: The genotype of HBV in Henan province is mainly type B and type C. |
| Keywords: | hepatitis B virus genotype distribution |
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