自拟乳腺方人工周期疗法结合心理干预治疗乳腺增生的临床研究

目的观察中药周期治疗配合心理干预治疗乳腺增生症的疗效及其作用机制。方法将152例乳腺增生分为三苯氧胺对照组(对照1组)、自拟乳腺方周期治疗组(对照2组)、心理干预组(对照3组)及自拟乳腺方周期治疗配合心理干预组(治疗组)。治疗3个月,观察疗效并检测治疗后患者血清雌二醇(E_2)、孕酮(P)水平及治疗前后焦虑情绪(HAMA评分)。结果治疗组疗效优于各对照组(P<0.05);治疗后治疗组焦虑情绪(HAMA评分)较治疗前明显下降(P<0.05),治疗组治疗后HAMA评分与对照3组比较无明显差异(P>0.05),但与对照1组及比较2组差异明显(P<0.01);治疗后,治疗组雌二醇(E_2)水平明显低于对照1组及对照2组(P<0.05),与对照3组比较无显著性差异(P>0.05)。孕酮(P)水平明显高于对照1组及对照2组(P<0.05),与对照3组比较亦无显著性差异(P>0.05)。结论自拟乳腺方人工周期疗法结合心理干预治疗乳腺增生,能提高疗效,其它机制可能是通过心理干预后缓解患者情绪,降低血清雌二醇水平,提高孕酮水平有关。

Observation on Hyperplasia of Breast Glands Treated with Herbal Periodic Treatment and Psychological Intervention Therapy

Objective To observe the curative effect and/of combination of periodic treatment and psychological intervention therapy.Methods 152 patients were randomly divided into 4 groups.The treatment group was treated with herbal periodic treatment and psychological intervention therapy.The control group 1 was treated with tamoxifen.The control group 2 was treated with herbal periodic treatment.The control group 3 was treated with psychological intervention therapy.Observing the curative effect and testing estradiol and progesterone and HAMA scores after 3 months treatment.Results The curative effect rate of treatment group was much better than 3 control groups.（P〈0.05）.The anxiety（HAMA scores） in treatment group had lowered down significantly.（P〈0.05）.The anxiety（HAMA scores） had significant difference between the treatment group and control group 1 and 2.（P〈0.01）,but had no significant difference in control group 3（P〉0.05）,and level of estradiol and progesterone had significant difference between the treatment group and control group 1 and 2（P〈0.05）.But had no significant difference in group 3（P〉0.05）.Conclusion Herbal periodic treatment and psychological intervention therapy had much better curative effect in the treatment of hyperplasia of breast glands.The cause may be relax anxiety,and lower E_2.and improve p.