对肝功能衰竭的猪行异位部分肝移植的效果评价

目的 探讨在猪急性缺血性肝功能衰竭时行辅助性异位部分肝移植的作用。 方法在缩窄门静脉8 5％以上的同时,对结扎及不结扎肝动脉的家猪体内配对开展辅助性异位部分肝移植,监测受体存活情况、肝功能、肝脏血流情况、病理及供肝胆汁分泌情况。 结果 在缩窄门静脉85％以上并结扎肝动脉的受体肝脏体积缩小,病理提示大片肝细胞坏死,在缩窄门静脉85％以上而未结扎肝动脉的受体肝脏色泽正常,病理肝细胞无明显异常;植入肝体积增大,病理提示肝细胞存活良好并有分裂增生。 结论 受体肝动脉结扎、门静脉缩窄可以造成急性肝功能衰竭模型;辅助性异位部分肝移植能纠正肝功能衰竭;保留受体肝脏动脉血供、减少门静脉血供对受体肝脏功能无严重影响。

Effect of auxiliary heterotopic partial liver transplantation on the pig with acute ischemic liver failure

Objective To study the effect of auxiliary heterotopic partial liver transplantation on the pig with acute ischemic liver failure. Methods When portal vein was shrinked more than 85 percent and artery was ligated or reserved, auxiliary heterotopic partial liver transplantation was performed in the pigs. The living condition, liver function, blood supply, pathological change and bile secretion of donor liver were observed, analysed and summarized. Results In the artery-ligated pigs, the volume of original liver reduced and the hepatocytes were necrotic evidently. While in the artery-reserved pigs, the colour and hepatocytes of original liver were normal. The volume of donor liver augmented, and the hepatocytes lived and proliferated well. Conclusions Liver artery-ligated and portal vein-shrinker can result in acute ischemic liver failure, and auxiliary heterotopic partial liver transplantation is effective to treat this liver failure, reducing portal vein blood supply is little harmful to liver.