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Grp-94、Paxillin、P-选择素在子宫内膜癌中的表达及其意义研究
引用本文:韩晓华,鲁静,陈晓. Grp-94、Paxillin、P-选择素在子宫内膜癌中的表达及其意义研究[J]. 中国妇幼保健, 2011, 26(14): 2190-2192
作者姓名:韩晓华  鲁静  陈晓
作者单位:1. 新疆石河子人民医院妇产科,新疆,石河子,832000
2. 新疆医科大学基础医学院病理学教研室
摘    要:目的:研究葡萄糖调节蛋白94(G rp-94)、桩蛋白(Paxillin)、P-选择素(P-selectin)在子宫内膜癌组织中的表达及意义。方法:免疫组化S-P法检测子宫内膜癌患者50例,观察肿瘤相关基因G rp-94、Paxillin、P-选择素的表达与子宫内膜癌发生、浸润及转移的关系。结果:①50例子宫内膜癌组织中,G rp-94、Paxillin、P-选择素阳性表达率分别为68.0%、54.0%和60.0%。②G rp-94在子宫内膜癌不同组织学分级中的表达差异无统计学意义(P>0.05),但从直观看随着分化程度的降低,G rp-94的阳性表达增高。Paxillin、P-选择素在不同组织学分级中的表达差异均有统计学意义(P<0.05)。三者在有、无淋巴结转移的子宫内膜癌患者中的表达差异均有统计学意义(P<0.05)。结论:G rp-94、Paxillin、P-选择素在子宫内膜癌的发生发展过程中关系密切,与手术病理分期关系不密切,可成为预测子宫内膜癌转移及预后的标志物。

关 键 词:Grp-94  Paxillin  P-选择素  子宫内膜癌

Study on the expression and the clinical pathology significance of Grp-94, Paxillin, P-selectin in endometrium carcinoma
HAN Xiao-Hua,LU Jing,CHEN Xiao. Study on the expression and the clinical pathology significance of Grp-94, Paxillin, P-selectin in endometrium carcinoma[J]. Maternal and Child Health Care of China, 2011, 26(14): 2190-2192
Authors:HAN Xiao-Hua  LU Jing  CHEN Xiao
Affiliation:HAN Xiao-Hua,LU Jing,CHEN Xiao.People's Hospital of Shihezi,Shihezi 832000,Xinjiang,China
Abstract:Objective:To study the expression and the clinical pathology significance of Grp-94,Paxillin,the P-selectin in the endometrium cancer tissues.Methods:50 patients with endometrium cancer were tested by immunohistochemistry S-P technique in tumor related gene Grp-94,Paxillin,the P-selectin.The relationship among the expression and occurrence and the infiltration and the shift were analyzed.Results: ① In 50 endometrium cancer tissurs,the positive rate of Grp-94,Paxillin,p-selectin was respectively 68.0 %,54.0%,60.0%.②There was no significant difference in the expression of Grp-94,but from the perspective of visual,the positive expression of Grp-94 increased with the reduction of degree of differentiation.There were significant differences in the expression of Paxillin and p-selectin in different histological classification(P<0.05).In addition,there ass the difference with lymphnode metastas in carcinoma tissues without lymphnode metastasis(P<0.05).Conclusion:It is suggested that Grp-94,Paxillin,the P-selectin have a close relationship with the endometrium metastasis and the prognosis and no closed relation with surgery pathology stages.
Keywords:Grp-94  Paxillin  P-selectin  Endometrium carcinoma  
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