晚期结直肠癌的化疗进展

转移性结直肠癌是癌症相关死亡的主要原因之一。对于所有转移性疾病来说手术切除可以治愈部分患者，但大部分患者需要考虑全身化疗作为最佳的姑息治疗。多年来，晚期结直肠癌的有效治疗局限于氟尿嘧啶。20世纪90年代出现的另外两个药物伊立替康和奥沙利铂被发现对晚期结直肠癌有效。近来，新的分子靶向药物bevacizumab和cetuximab首次显示了疗效。这里我们回顾了晚期结直肠癌治疗的最新进展和对于这些患者的最佳治疗。

Developments in the chemotherapy treatment for advanced colorectal cancer

Metastatic colorectal cancer is a major cause of cancer-related mortality. Surgical resection of all known metastatic disease can be curative in selected patients. The majority of patients,however,require systemic chemotherapy as optimal palliative treatment for their disease. For years,effective treatment for advanced colorectal cancer was limited to fluorouracil. In the 1990s,two additional agents,irinotecan and oxaliplatin,were found to have activity against advanced colorectal cancer. Recently,new molecular targeted agents,bevacizumab and cetuximab,were for the first time demonstrated efficacy. Herein,we review recent developments in treatment for metastatic colorectal cancer and implication for optimal treatment in these patients.