| 大鼠自身免疫性葡萄膜视网膜炎眼部细胞因子信号抑制因子的表达 |
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| 引用本文： | 梁亮,王红,彭晓燕. 大鼠自身免疫性葡萄膜视网膜炎眼部细胞因子信号抑制因子的表达[J]. 国际眼科杂志, 2009, 9(1): 31-34. DOI: 10.3969/j.issn.1672-5123.2009.01.010 |
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| 作者姓名： | 梁亮 王红 彭晓燕 |
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| 作者单位： | 首都医科大学附属北京同仁眼科中心 北京市眼科学与视觉科学重点实验室,中国北京市,100730;首都医科大学附属北京同仁眼科中心 北京市眼科学与视觉科学重点实验室,中国北京市,100730;首都医科大学附属北京同仁眼科中心 北京市眼科学与视觉科学重点实验室,中国北京市,100730 |
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| 摘 要： | 目的:大鼠自身免疫性葡萄膜视网膜炎(experimentalautoimmune uveoretinitis,EAU)大鼠模型眼部研究细胞因子信号抑制因子(suppressor of cytokine signaling,SOCS)的表达。方法:用光感受器间维生素A类结合蛋白(interphotoreceptorretinoid-binding protein,IRBP)免疫Lewis鼠160只后,在眼组织切片上应用SOCS多克隆抗体进行免疫组织化学染色,观察其在眼组织中的表达并与正常大鼠40只做对照。结果:用IRBP免疫Lewis鼠后,免疫组织化学染色发现在虹膜、睫状体和视网膜部位可见SOCS-1和SOCS-5蛋白表达;而在正常Lewis鼠未见SOCS蛋白表达。统计学结果显示,SOCS-1和SOCS-5蛋白表达与EAU严重程度呈正相关(r1=0.954,r2=0.963,P<0.01)。结论:自身免疫性葡萄膜视网膜炎Lewis鼠出现SOCS阳性表达细胞在EAU的发病过程中起了一定的作用。
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| 关 键 词： | SOCS 实验性自身免疫性葡萄膜视网膜炎 |
Study on the expression of suppressor of cytokine signaling in experimental autoimmune uveoretinitis |
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| Liang Liang,Hong Wang,Xiao-Yan Peng. Study on the expression of suppressor of cytokine signaling in experimental autoimmune uveoretinitis[J]. International Eye Science, 2009, 9(1): 31-34. DOI: 10.3969/j.issn.1672-5123.2009.01.010 |
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| Authors: | Liang Liang Hong Wang Xiao-Yan Peng |
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| Affiliation: | Liang Liang,Hong Wang,Xiao-Yan PengBeijing Ophthalmology & Visual Sciences Key Lab,Beijing Tongren Eye Center,Beijing Tongren Hospital,Capital Medical University,Beijing 100730,China |
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| Abstract: | AIM:To investigate the expression of suppressor of cytokine signaling(SOCS)positive cells involved in experimental autoimmune uveoretinitis(EAU).METHODS:Immunohistochemical staining was performed using polyclonal antibodies to SOCS on ocular sections of 160 Lewis rats after immunized with interphotoreceptor retinoid-binding protein(IRBP),and 40 normal ones as controls.RESULTS:SOCS positive cells were not detected in ocular sections from normal Lewis rats.In the ocular sections of Lewis rats with EAU,SOCS-1 ... |
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| Keywords: | SOCS |
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