| Calpain在噪声损害毛细胞中的角色 |
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| 引用本文： | 丁大连,李明,王坚,Salvi．RJ. Calpain在噪声损害毛细胞中的角色[J]. 中国中西医结合耳鼻咽喉科杂志, 2000, 0(4) |
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| 作者姓名： | 丁大连 李明 王坚 Salvi．RJ |
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| 作者单位： | 美国纽约州立布法罗大学听力耳聋研究中心(丁大连,王坚,Salvi．RJ),佳木斯大学临床医学院耳鼻咽喉科(李明) |
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| 摘 要： | 目的：了解Calpain在噪声损害耳蜗毛细胞中所扮演的角色。方法观察Calpain免疫细胞化学反应产物在噪声损害中的变化。结果正常对照耳蜗样品中未见Calpain活性显示,但噪声损害耳蜗样品中可见外毛细胞底部及其神经末梢区域出现大量的Calpain。结论噪声引起的耳蜗毛细胞破坏可能与Calpain的激活及其降解功能有关。
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| 关 键 词： | Calpain 噪声 耳蜗 毛细胞 |
Role of calpain in noise induced hair cell trauma |
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| Ding Dalian, Li Ming, Wang jian et al. Role of calpain in noise induced hair cell trauma[J]. Chinese Journal of Otorhinolaryngology of Integrated Traditional and Western Medicine, 2000, 0(4) |
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| Authors: | Ding Dalian Li Ming Wang jian et al |
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| Abstract: | Objective To know the role of calpain in noise induced cochlear trauma.Method The activity of calpain was revealed throught immunocytochemistry. Results Calpain appears in the inner and outer hair cells and its nerve endings after noise exposure, But it is never shown in normal control samples. Conclusion Noise induced hair cell lesion maybe related to the actlvation of calpain and its proteolysis function. |
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| Keywords: | Calpain Noise Cochlea Hair cell |
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