高血压病患者动态血压与动脉顺应性的相关性研究

目的:探讨高血压病患者动脉顺应性的变化,及其与动态血压监测(ABPM)各指标间的相互关系。方法:对262例高血压病患者和104例正常人进行动态血压监测(ABPM)和脉搏波速度(PWV)测定。结果:高血压组的颈动脉-桡动脉(G-R)PWV、颈动脉-股动脉(C-F)PWV,24 h、白昼及夜间平均血压,平均脉压,心率,血压负荷均显著高于正常对照组(P<0.05~<0.01)。C-F PWV及C-R PWV与24 h、白昼及夜间平均血压,心率,血压负荷均呈显著正相关(r=0.108~0.406,P<0.05~<0.001)。C-F PWV比C-R PWV与平均收缩压和收缩压负荷的相关性更强。C-F PWV与动态脉压、年龄显著正相关(r=0.205~0.406,P<0.001)。结论:动脉顺应性减退是高血压的重要改变,大动脉顺应性与动态脉压、收缩压和年龄的关系更为密切。

Relationship between ambulatory blood pressure and arterial compliance in patients with essential hypertension

Objective:To investigate the change of arterial compliance in patients with essential hypertension(EH) and the relationship between ambulatory blood pressure and arterial compliance.Methods:Pulse wave velocity(PWV)and ambulatory blood pressure monitoring(ABPM) were performed in 262 EH patients and 104 normal subjects.Results:Carotid-radial PWV,carotid-femoral PWV,mean blood pressure of 24 h,daytime and night, ambulatory pulse pressure,heart rate and load of blood pressure were significantly higher in hypertensive group than those in normal group(P<0.05~<0.001).Carotid-radial PWV and carotid-femoral PWV were positively correlated with mean blood pressure of 24 h,daytime and night,heart rate and load of blood pressure(r=0.108~0.406,P<0.05~<0.001).The associations of the mean systolic blood pressure and load of systolic blood pressure with carotid-femoral PWV were stronger than those with carotid-radial PWV.Carotid-femoral PWV was positively related to ambulatory pulse pressure and age r=0.205~0.406,P<0.001 all).Conclusion:The decrease of arterial compliance is major change in hypertension.The change in large arterial compliance is more related to ambulatory pulse pressure,systolic blood pressure and age.