米氮平与氟西汀治疗老年抑郁症的对照研究

目的:观察米氮平与氟西汀治疗老年抑郁症的临床疗效和安全性。方法:将60例老年抑郁症患者随机分为米氮平组(30例)和氟西汀组(30例),疗程6周,采用汉密尔顿抑郁量表(HAMD)评定疗效,用不良反应量表(TESS)评估不良反应和安全性。结果:米氮平组治疗1周有效率高于氟西汀组,疗程结束时两组疗效和HADM评分差异无显著性,不良反应少。结论:米氮平与氟西汀治疗老年抑郁症疗效相似,米氮平起效快。

Comparative study of mirtazapine and fluoxetine in treatment of senile depression

ObjectiveTo observe clinical efficacy and safety of mirtazapine and fluoxetine in treatment of senile depression.Methods：60 senile cases with depression were randomly divided into mirtazapine group （30 cases） and fluoxetine group （30 cases）,and they were treated for 6 weeks. Hamilton depression scale （HAMD） was used to assess the efficacy, and treatment emergent symp鄄tom scale （TESS） was applied to evaluate the adverse reactions and safety. Results： 1 week after the treatment, the effective rate ofmirtazapine group was higher than that of fluoxetine group. There were no significant differences in the efficacies and HAMD scores be-tween the two groups after the treatment. Moreover, there were a few adverse reactions. Conclusions： Mirtazapine and fluoxetine in thetreatment of senile depression have similar effects, but mirtazapine has an earlier response.