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| Generation of patient-specific pluripotent stem cells and directed differentiation of embryonic stem cells for regenerative medicine | |
| 引用本文： | Minyue M,Jiahao Sh,Zuomin Zhou,Qi Zhou,Qingzhang Li. Generation of patient-specific pluripotent stem cells and directed differentiation of embryonic stem cells for regenerative medicine[J]. 南京医科大学学报(自然科学版), 2008, 28(3): 135-142 |
| 作者姓名： | Minyue M Jiahao Sh Zuomin Zhou Qi Zhou Qingzhang Li |
| 作者单位： | Minyue Ma a，Jiahao Sha b，Zuomin Zhou b，Qi Zhou c，Qingzhang Li a，*a Life Science College，Northeast Agriculture University，Harbin 150030，Heilongjiang Province，ChinabLab of Reproductive Medicine，Department of Histology and Embryology，Nanjing Medical University，Nanjing 210029，Jiangsu Province，Chinac State Key Laboratory of Reproductive Biology，Institute of Zoology，Chinese Academy of Sciences，Beijing 100101，China |
| 摘 要： | Embryonic stem(ES) cells are pluripotent cells that can give rise to derivatives of all three embryonic germ layers. Due to its characteristics, the patient-specific ES cells are of great potential for transplantation therapies. Several strategies can reprogramme somatic cells back to pluripotent stem cells: nuclear transfer, fusion with ES cells, treatment with cell extract and induction by specific factors. Considering the future clinical use, the differentiation from ES to neurons, cardiomyocytes and many other types of cells currently provide basic cognition and experience to regenerative medicine. This article will review two courses, the reprogramming of differentiated cells and the differentiation of ES cells to specific cell types. |
| 关 键 词： | 胚胎干细胞 再生医学 多能干细胞 细胞再生 |
| 收稿时间： | 2007-12-10 |
Generation of patient-specific pluripotent stem cells and directed differentiation of embryonic stem cells for regenerative medicine |
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| Minyue M,Jiahao Sh,Zuomin Zhou,Qi Zhou and Qingzhang Li. Generation of patient-specific pluripotent stem cells and directed differentiation of embryonic stem cells for regenerative medicine[J]. Acta Universitatis Medicinalis Nanjing, 2008, 28(3): 135-142 | |
| Authors: | Minyue M Jiahao Sh Zuomin Zhou Qi Zhou Qingzhang Li |
| Affiliation: | 1. Life Science College, Northeast Agriculture University, Harbin 150030, Heilongjiang Province, China 2. Lab of Reproductive Medicine, Department of Histology and Embryology, Nanjing Medical University, Nanjing 210029, Jiangsu Province, China 3. State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China |
| Abstract: | Embryonic stem(ES) cells are pluripotent cells that can give rise to derivatives of all three embryonic germ layers. Due to its characteristics, the patient-specific ES cells are of great potential for transplantation therapies. Several strategies can reprogramme somatic cells back to pluripotent stem cells: nuclear transfer, fusion with ES cells, treatment with cell extract and induction by specific factors. Considering the future clinical use, the differentiation from ES to neurons, cardiomyocytes and many other types of cells currently provide basic cognition and experience to regenerative medicine. This article will review two courses, the reprogramming of differentiated cells and the differentiation of ES cells to specific cell types. |
| Keywords: | stem cell reprogramming differentiation regenerative medicine |
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