| 合成鱼腥草素对环磷酰胺模型小鼠免疫功能的影响 |
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| 引用本文： | 邵兰,于庆海,徐静华,李霞,张予阳,张何. 合成鱼腥草素对环磷酰胺模型小鼠免疫功能的影响[J]. 沈阳药科大学学报, 2000, 17(2): 132-135 |
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| 作者姓名： | 邵兰 于庆海 徐静华 李霞 张予阳 张何 |
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| 作者单位： | 1. 沈阳药科大学中药系,沈阳,110015
2. 辽宁卫生职工医学院药学系,沈阳,110005 |
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| 摘 要： | 对于环磷酰胺所致免疫功能低下模型小鼠 ,灌胃给予合成鱼腥草素 6 0mg/kg、12 0mg/kg能明显增加环磷酰胺所致免疫功能低下模型小鼠的脾脏指数、外周血淋巴细胞ANAE阳性百分率 ;增强单核巨噬细胞吞噬功能、迟发型超敏反应强度及ConA诱导的脾脏T淋巴细胞增殖能力 ;对胸腺指数则无明显影响 ;合成鱼腥草素 12 0mg/kg还能明显增强环磷酰胺模型小鼠血清溶血素的生成及脾脏空斑形成细胞溶血能力 .
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| 关 键 词： | 合成鱼腥草素 环磷酰胺 免疫调节 |
The Effect of Houttuyninum on Immunologic Function in Mice Treated with Cyclophosphamide |
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| Shao Lan,Yu Qinghai,Xu Jinghua,Li Xia,Zhang Yuyang,Zhang He. The Effect of Houttuyninum on Immunologic Function in Mice Treated with Cyclophosphamide[J]. Journal of Shenyang Pharmaceutical University, 2000, 17(2): 132-135 |
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| Authors: | Shao Lan Yu Qinghai Xu Jinghua Li Xia Zhang Yuyang Zhang He |
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| Abstract: | HOU by i.g. at 60 mg/kg or 120 mg/kg significantly strengthened the phagocytosing function of monocytemacrophage system, and delayed type of hypersensitivity (DTH) reaction, ConAinduced splenocyte proliferation significantly enhanced the spleen index, ANAE ( ) cell percentage of peripheral blood lymphocytes in mice treated with cyclophosphamide. However, the thymus index did not change obviously. HOU by i.g at 120 mg/kg remarkably increased the development of serum hemolysin and the production of the spleen plaque forming cell (PFC) in cyclophosphamide mice. |
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| Keywords: | houttuyninum cyclophosphamide immunoregulation |
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