| 粉防己碱对缺氧所致大鼠皮层神经元钙通道功能变化的影响 |
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| 引用本文： | 王中峰,薛春生,周歧新,万子兵,罗全生. 粉防己碱对缺氧所致大鼠皮层神经元钙通道功能变化的影响[J]. 中国药理学与毒理学杂志, 2000, 14(1): 58-61 |
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| 作者姓名： | 王中峰 薛春生 周歧新 万子兵 罗全生 |
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| 作者单位： | ：王中峰(重庆医科大学药理学教研室， 重庆 400046）;薛春生(重庆医科大学药理学教研室， 重庆 400046）;周歧新(重庆医科大学药理学教研室， 重庆 400046）;万子兵（第三军医大学生理学教研室， 重庆 400038) |
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| 摘 要： | 用细胞贴附式膜片钳单通道记录技术 ,研究了粉防己碱 ( Tet)对缺氧状态下大鼠大脑皮层神经元L-和 N-型钙通道变化的影响 .结果发现 ,Tet7.5,1 5和 30 μmol·L-1浓度依赖性缩短由缺氧诱导的L-和 N-型钙通道开放时间增加 ,降低开放概率 .Tet对皮层神经元 L-和 N-型钙通道的这一作用可能是其脑缺氧保护作用的机理之一 .
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| 关 键 词： | 粉防己碱 膜片钳技术 神经元 钙通道 低氧 |
| 收稿时间： | 1998-10-27 |
| 修稿时间： | 1998-10-27 |
Effect of tetrandrine on the functional changes in calcium channels induced by anoxia in cerebral cortical neurons acutely isolated from rats |
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| WANG Zhong-Feng. Effect of tetrandrine on the functional changes in calcium channels induced by anoxia in cerebral cortical neurons acutely isolated from rats[J]. Chinese Journal of Pharmacology and Toxicology, 2000, 14(1): 58-61 |
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| Authors: | WANG Zhong-Feng |
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| Affiliation: | (1. Department of Pharmacology, Chongqing University of Medical Sciences, Chongqing 400046, China; 2. Department of Physiology, The Third Military Medical University, Chongqing 400038, China) |
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| Abstract: | Using cell-attached configuration of patch clamp single channel recording technique the effect of tetrandrine(Tet) on the functional changes in L- and N-type calcium chennal induced by anoxia was studied. The results indicated that Tet 7.5, 15 and 30 mmol·L-1 inhibited the increase in open time constants and open state probability of L- and N-type calcium induced by anoxia in concentration-dependent manner. The results suggest that Tet inhibit the long-lasting open of L- and N-type calcium channels induced by anoxia in rat cerebral cortical neurons, which may be one of its protective mechanisms against cerebral anoxia. |
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| Keywords: | tetrandrine patch clamp technique neurons calcium channels anoxia |
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