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| 扩张型心肌病患者心肌Cx43基因的表达 | |
| 引用本文： | 陈新山,徐顺清,郭晖,闫杰,刘念,张益鹄. 扩张型心肌病患者心肌Cx43基因的表达[J]. 华中科技大学学报(医学版), 2011, 40(1): 88-90,94. DOI: 10.3870/j.issn.1672-0741.2011.01.020 |
| 作者姓名： | 陈新山 徐顺清 郭晖 闫杰 刘念 张益鹄 |
| 作者单位： | 1. 华中科技大学同济医学院法医学系,武汉,430030 2. 华中科技大学同济医学院环境医学研究所,武汉,430030 3. 华中科技大学同济医学院附属同济医院器官移植研究所,武汉,430030 4. 华中科技大学同济医学院附属同济医院心内科,武汉,430030 |
| 基金项目： | 武汉市科技攻关计划资助项目，湖北省科技攻关计划资助项目 |
| 摘 要： | 目的探讨晚期扩张型心肌病(DCM)患者心肌连接蛋白43(Cx43)基因表达水平及其意义。方法 DCM病例及标本是2002～2003年华中科技大学同济医学院附属同济医院对4例晚期DCM患者进行心脏移植手术切除心脏的心肌;其中男2例、女2例,年龄分别为14、44、45和55岁。对照组4例为同期颅脑损伤和毒品中毒致死者,均为男性,年龄分别为24、29、30和37岁;死因为颅脑损伤3例、毒品中毒1例。每例心脏进行常规病理学检查并取材后,应用逆转录PCR技术定量检测左心室心肌Cx43基因表达水平,并进行比较分析。结果 DCM患者心肌Cx43基因定量检测结果为(0.188±0.167),对照组为(0.440±0.096),两组比较差异有统计学意义(P=0.025)。结论晚期DCM患者心肌Cx43基因表达水平下降,这种心肌Cx43基因表达水平下降可能与DCM患者发生心衰、心律失常和猝死有关。 |
| 关 键 词： | 扩张型心肌病 连接蛋白43基因 心脏移植 |
Expression of Connexin43 Gene in Myocardia of Patients with Dilated Cardiomyopathy |
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| Chen Xinshan,Xu Shunqing,Guo Hui et al. Expression of Connexin43 Gene in Myocardia of Patients with Dilated Cardiomyopathy[J]. Journal of Huazhong University of Science and Technology(Health Sciences), 2011, 40(1): 88-90,94. DOI: 10.3870/j.issn.1672-0741.2011.01.020 | |
| Authors: | Chen Xinshan Xu Shunqing Guo Hui et al |
| Affiliation: | Chen Xinshan1,Xu Shunqing2,Guo Hui3 et al1Department of Forensic Pathology,Tongji Medical College,Huazhong University of Science andTechnology,Wuhan 430030,China2Institute of Environmental Medicine,China3Institute of Organ Tranplantation,Tongji Hospital,Huazhong Universityof Science and Technology,China |
| Abstract: | Objective To investigate the significance and expression level of connexin43(Cx43) gene in myocardia of patients with dilated cardiomyopathy(DCM).Methods The myocardial samples of 4 cases were obtained in the left ventricular walls of hearts transplanted from the DCM patients who hospitalized in Tongji Hospital from December 2002 to July,2003.There were 2 males and 2 females with the age being 14,44,45 and 55 years old respectively.The myocardial samples of 4 male cases in control group were obtained from t... |
| Keywords: | dilated cardiomyopathy connexin43 gene heart transplantation |
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