| X射线对小鼠腹腔巨噬细胞表达B7-1和B7-2的影响 |
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| 引用本文： | 金顺子,刘树铮. X射线对小鼠腹腔巨噬细胞表达B7-1和B7-2的影响[J]. 吉林大学学报(医学版), 2001, 27(2): 111-113 |
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| 作者姓名： | 金顺子 刘树铮 |
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| 作者单位： | 卫生部放射生物学重点实验室!吉林长春130021 |
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| 基金项目： | 国家自然科学基金;39570188; |
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| 摘 要： | 目的 :观察 X射线全身照射对小鼠腹腔巨噬细胞表达 B7- 1和 B7- 2的影响。方法 :采用免疫组织化学法 ( ABC法 )。结果 :小鼠腹腔巨噬细胞表达 B7- 2达到高峰的时间早于 B7- 1,而且 B7- 2表达幅度也高于 B7- 1。剂量 -效应关系的研究表明 ,B7- 1和 B7- 2的表达均在 0 .0 75Gy剂量点出现峰值 ,而在较大剂量照射时也出现一个峰值。但在不同分度分析结果中发现 ,低剂量 X射线照射组的高密度细胞百分数比较大剂量组多。结论 :B7分子的表达上调可能是参与低剂量电离辐射免疫增强效应的重要因素。
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| 关 键 词： | X射线 小鼠腹腔巨噬细胞 B7-1 B7-2 |
| 文章编号： | 0253-3707(2001)02-0111-03 |
| 修稿时间： | 2000-09-25 |
Effect of X-rays on the expression of B7-1 and B7-2 in per itoneal macrophages |
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| JIN Shun-zi,LIU SHU-ZHENG. Effect of X-rays on the expression of B7-1 and B7-2 in per itoneal macrophages[J]. Journal of Jilin University: Med Ed, 2001, 27(2): 111-113 |
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| Authors: | JIN Shun-zi LIU SHU-ZHENG |
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| Affiliation: | The MH Radiobiology Research Unit,School of Preventive Medicine ,Jilin University,;The MH Radiobiology Research Unit,School of Preventive Medicine ,Jilin University, |
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| Abstract: | Objective: The effect of whole body irradiation (WBI) on B7 1 and B7 2 expression in peritoneal macrophages in mice was observed.Methods:Immunohistochemistry (ABC method) was used. Results: The upregulation of B7 2 expression induced by WBI X rays appeared earlier than that of B7 1.The study on the dose effect relationship showed that the expression of both B7 1 and B7 2 reached its peak at 0.075 Gy after WBI X rays. The doses inducing a second peak of B7 1 and B7 2 upregulation were higher in the case of WBI in comparison with in vitro irradiation. Conclusion: The results suggested that the upregulation of expression of B7 molecules after irradiation might be an important factor involved in the enhancing effect of low dose radiation on immunity. [ |
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| Keywords: | X rays peritoneal macrophage B7 1 B7 2 |
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