| 绿茶提取物清除单线态氧的作用及抗脂质过氧化效应 |
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| 引用本文： | 吴元德,邱琦.绿茶提取物清除单线态氧的作用及抗脂质过氧化效应[J].中国医学科学院学报,1993,15(5):354-359. |
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| 作者姓名： | 吴元德 邱琦 |
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| 作者单位： | 中国医学科学院，中国医学科学院，中国医学科学院 中国协和医科大学 基础医学研究所，北京，中国协和医科大学 基础医学研究所，北京，中国协和医科大学 基础医学研究所，北京 |
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| 摘 要： | 光敏化剂玫瑰红光照后产生单线态氧(~1O_2),以N,N-二甲基-4-亚硝基苯胺(DM-NA)被漂白作用测定~1O_2的产生及清除。绿茶提取物(GTE)可以清除光敏氧化反应系统产生的~1O_2,在起始阶段作用更显著,随GTE浓度增加清除作用加强。新配制的GTE溶液清除~1O_2的效果较陈旧溶液为佳。GTE可以防护单线态氧造成的红细胞膜及微粒体脂质过氧化作用,达到一定浓度时可以完全抑制丙二醛的产生。
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| 关 键 词： | 绿茶提取物 玫瑰红 单线态氧 脂质过氧化 |
Scavenging Action of Green Tea Extracts on Singlet Oxygen and Preventive Effect on Lipid Peroxidation |
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| Wu Yuande,.Scavenging Action of Green Tea Extracts on Singlet Oxygen and Preventive Effect on Lipid Peroxidation[J].Acta Academiae Medicinae Sinicae,1993,15(5):354-359. |
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| Authors: | Wu Yuande |
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| Abstract: | Singlet oxygen (1O2) produced hy illuminated photosensitizer Rose Bengal was detected by its bleaching effect on N,N-dimethylnitrosoaniline(DMNA). The 1O2 could be scavenged by green tea extracts (GTE) , with the scavenging action being obvious at the early stage of photosensitized oxidation. The higher the concentration of GTE in the photooxidation reaction system, the stronger the 1O2 scavenging action. The scavenging effect of the fresh GTE solution on singlet oxygen was better than that of old solution. The preventive effects of GTE on lipid peroxidation induced by 1O2 in ghosts and microsomal membranes were also observed. Malondialdehyde (MDA) produc-tion was found to be completely inhibited by a high concentration of GTE in the reaction system. |
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| Keywords: | green tea extracts Rose Bengal singlet oxygen lipid peroxidation |
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