| 心舒滴丸对冠脉结扎所致大鼠长期心肌缺血模型的影响 |
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| 引用本文： | 余燕,龙子江,金花荣,张敬杨,王靓,陈明,王芳. 心舒滴丸对冠脉结扎所致大鼠长期心肌缺血模型的影响[J]. 中国实验方剂学杂志, 2010, 16(3): 109-111 |
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| 作者姓名： | 余燕 龙子江 金花荣 张敬杨 王靓 陈明 王芳 |
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| 作者单位： | 安徽中医学院药理教研室,合肥,230038 |
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| 摘 要： | ![]()
目的:观察心舒滴丸对冠脉结扎所致大鼠长期心肌缺血模型心肌的影响,并探讨其作用机制。方法:将大鼠随机分成假手术组、模型组、阳性组、心舒滴丸低,中,高剂量组,各组大鼠(除假手术组外)采用结扎冠状动脉左前降支造成心肌梗死模型,各鼠ig给药28 d,分别测定手术前及手术后即刻,1,3,7,10,14,21,28 d各组大鼠的心电图S-T段,心肌梗死率及大鼠血浆中血栓素(TXB2)、6酮前列腺素(6-keto-PGF1α)的含量。结果:心舒滴丸能显著抑制心肌缺血大鼠心电图S-T段升高,缩小用药组大鼠心肌梗死面积;各用药组大鼠血浆中血栓素(TXB2)显著降低、6酮前列腺素(6-keto-PGF1α)含量升高。结论:心舒滴丸对冠状动脉结扎所致大鼠长期心肌缺血模型的损伤心肌有一定的保护作用。
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| 关 键 词： | 心舒滴丸 冠脉结扎 长期心肌缺血 大鼠 |
| 收稿时间： | 2009-08-18 |
Effect of Xinshu Pills on Coronary Artery Ligation in the Long-term Myocardial Ischemia of Rats |
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| YU Yan,LONG Zi-jiang,JIN Hua-rong,ZHANG Jing-yang,WANG Liang,CHEN Ming and WANG Fang. Effect of Xinshu Pills on Coronary Artery Ligation in the Long-term Myocardial Ischemia of Rats[J]. China Journal of Experimental Traditional Medical Formulae, 2010, 16(3): 109-111 |
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| Authors: | YU Yan LONG Zi-jiang JIN Hua-rong ZHANG Jing-yang WANG Liang CHEN Ming WANG Fang |
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| Affiliation: | Department of Pharmacology ,Anhui College of Tranditional Chinese Medicine,Hefei 230038,China;Department of Pharmacology ,Anhui College of Tranditional Chinese Medicine,Hefei 230038,China;Department of Pharmacology ,Anhui College of Tranditional Chinese Medicine,Hefei 230038,China;Department of Pharmacology ,Anhui College of Tranditional Chinese Medicine,Hefei 230038,China;Department of Pharmacology ,Anhui College of Tranditional Chinese Medicine,Hefei 230038,China;Department of Pharmacology ,Anhui College of Tranditional Chinese Medicine,Hefei 230038,China;Department of Pharmacology ,Anhui College of Tranditional Chinese Medicine,Hefei 230038,China |
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| Abstract: | ![]()
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| Keywords: | Xinshu pills coronary artery ligation long-term myocardial ischemia rat |
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