葛根素磷脂复合物自乳化释药系统的处方优选

目的:优选葛根素磷脂复合物自乳化释药系统的处方工艺.方法:以乳化程度和乳滴粒径大小为指标,通过溶解度试验和相图绘制筛选处方中油相、非离子表面活性剂、助表面活性剂,确定最佳处方.结果:优选的处方工艺为油酸乙酯(油相)-聚山梨脂80(非离子表面活性剂)-无水乙醇(助表面活性剂)5:3:2,乳化时间40.53 s,平均粒径107.3 nm.结论:制备的葛根素磷脂复合物自乳化系统为黄色澄明液体,加水后可形成澄清透明并带淡蓝色乳光的乳液,且体系无起泡现象,乳化效果好.

Optimization of Formulation of Self-emulsifying Drug Delivery Systems of Puerarin Phospholipid Complex

Objective: To optimize formulation of self-emulsifying drug delivery systems of puerarin-soybean lecithin complex. Method: With the degree of emulsifying and particle size of emulsion droplet as indexes,oil phase,non-ionic surfactant and co-surfactant in the formulation were screened by solubility experiment and drawing phase diagram,and to determine optimum formulation. Result: Optimum formulation of the self emulsifying drug delivery system was as following:ethyloleate as oil phase,Tween-80 as nonionic surfactant and ethanol as co-surfactant,the proportion of them 5:3:2,emulsifying time 40.53 s,the average particle size 107.3 nm. Conclusion: Prepared self-emulsifying drug delivery systems of puerarin-soybean lecithin complex was yellow clear liquid,it could be a clear and transparent with light blue opalescent emulsion after adding water,and this system had good emulsifying effect without blistering.