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Absence of relaxation to lactate in human placental vessels of pregnancies with severe preeclampsia
Authors:Reinaldo Figueroa MD   Edilberto Martinez MD   Raisa P. Fayngersh MD   Hong Jiang MD   Hatim A. Omar MD   Nergesh Tejani MD  Michael S. Wolin PhD  
Affiliation:aDepartment of Physiology, New York Medical College, Valhalla, New York, USA;bDepartments of Obstetrics and Gynecology, New York Medical College, Valhalla, New York, USA
Abstract:
OBJECTIVE: Our objective was to determine whether the observed relaxation to lactate and other agents in placental vessels of normal pregnancies is altered in severe preeclampsia.STUDY DESIGN: Isolated placental arteries and veins from women with severe preeclampsia and uncomplicated term pregnancies were precontracted with prostaglandin F under 5% oxygen and 5% carbon dioxide with the balance nitrogen (Po2 35 to 38 torr) and then exposed to lactate (1 to 10 mmol/L, pH 7.4, n = 8 to 15), arachidonic acid (0.01 to 10 μmol/L, n = 6 to 13), nitroglycerin (1 nmol to 1 μmol/L, n = 4 to 12), or forskolin (0.01 to 10 μmol/L, n = 6 to 9). The response to lactate was also examined in placental vessels from appropriate-for-gestational-age preterm deliveries (n = 8) for comparison with a similar group with severe preeclampsia (n = 8). The t test and analysis of variance statistics were used.RESULTS: Relaxation to lactate was markedly inhibited in both placental arteries and veins of women with severe preeclampsia compared with vessels from uncomplicated term or preterm pregnancies. Responses to the other relaxing agents were not altered in the severely preeclampsia vessels.CONCLUSIONS: In severe preeclampsia absence of lactate-induced dilatation of placental vessels may contribute to the fetal complications associated with impaired blood flow and vasospasm.
Keywords:Preeclampsia   placental vessels   forskolin   lactate   nitroglycerin   arachidonic acid   placental circulation
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