The effect of polyethylene glycol and butyrate on anastomotic healingin the rat colon |
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| Authors: | P. Fa-Si-Oen P. van de Gender H. Putter N. Ectors A. D’Hoore B. Topal F. Penninckx |
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| Affiliation: | (1) Department of Abdominal Surgery, University Clinic Gasthuisberg, Leuven, Belgium;(2) Department of Medical Statistics, University of Leiden, Leiden, The Netherlands;(3) Department of Pathology, University Clinic Gasthuisberg, Leuven, Belgium |
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| Abstract: | ![]()
Background The use of mechanical bowel preparation is much debated. Methods We evaluated the effects of polyethylene glycol (PEG), with or without a single dose of 3.0 mmol butyrate (BUT), on the bursting pressure (BP) of an intact colon segment and a colon anastomosis in rats. Also, histopathologic damage was studied. Results In rats without colectomy, the mean BP was 159.2 mmHg (SD=18.9) after PEG treatment and 116.7 mmHg (SD=27.5) in controls (p=0.001). In rats with colectomy, the mean BP was 90.4 mmHg (SD=45.9) in the PEG group, 108.0 mmHg (SD=31.9) in the BUT group, and 102.7 mmHg (SD=44.7) in controls (p=0.44). No significant differences in histopathologic scores were observed between rats treated with PEG and controls. Conclusions PEG does not interfere with anastomotic healing in rats as measured by BP. No benefit of a single dose of butyrate was observed. An erratum to this article is available at . |
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| Keywords: | Colon Bursting pressure Rats Polyethylene glycol Butyrate |
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