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| 咪唑芳酸衍生物的合成及抗血小板聚集活性 | |
| 引用本文： | 周鹏,何勇,李家明,许勤龙,盛日正. 咪唑芳酸衍生物的合成及抗血小板聚集活性[J]. 中国现代应用药学, 2011, 28(5): 446-450 |
| 作者姓名： | 周鹏 何勇 李家明 许勤龙 盛日正 |
| 作者单位： | 安徽中医学院药学院，安徽省现代中药重点实验室，合肥 230031 |
| 基金项目： | 国家科技重大专项重大新药创制项目(2009ZX09103-123)；安徽省自然科学基金项目(070413118) |
| 摘 要： | 目的合成4个咪唑芳酸衍生物。方法以香草酸、丁香酸为起始原料,经Williamson醚化、亲核取代和水解反应,合成咪唑芳酸衍生物4 a~4 d。结果目标化合物的结构经IR、1H-NMR、13C-NMR及MS确证。结论初步的药理实验结果显示,在12 mmol·L-1浓度下,化合物4 a的血小板抑制率达到84.5%。 |
| 关 键 词： | 咪唑芳酸衍生物 抗血小板聚集 合成 |
| 收稿时间： | 2010-08-12 |
Synthesis of Imidazole-Aromatic Acid Derivatives and Their Inhibitory Effect on Platelet Aggregation |
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| ZHOU Peng,HE Yong,LI Jiaming,XU Qinlong and SHENG Rizheng. Synthesis of Imidazole-Aromatic Acid Derivatives and Their Inhibitory Effect on Platelet Aggregation[J]. The Chinese Journal of Modern Applied Pharmacy, 2011, 28(5): 446-450 | |
| Authors: | ZHOU Peng HE Yong LI Jiaming XU Qinlong SHENG Rizheng |
| Affiliation: | ZHOU Peng,HE Yong,LI Jiaming*,XU Qinlong,SHENG Rizheng(Department of Pharmacy,Anhui College of Traditional Chinese Medicine,Anhui Key Laboratory of Traditional Chinese Medicine,Hefei 230031,China) |
| Abstract: | OBJECTIVE To synthesize four new compounds of imidazole-aromatic acid derivatives. METHODS Imidazole-aromatic acid derivatives were prepared from vanillic acid, syringic acid via Williamson etherification, nucleophilic substitution, and hydroxylation. RESULTS The structures of the target compounds were confirmed by IR, 1H-NMR, 13C-NMR and MS. CONCLUSION Preliminary pharmacological results showed that the inhibitory effect on platelet aggregation of compound 4a at 12 mmol·L-1 was 84.5%. |
| Keywords: | imidazole-aromatic acid derivatives platelet aggregation inhibitory synthesis |
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