乌贼墨多糖对环磷酰胺致小鼠部分脏器损伤的缓解效应

目的探讨乌贼墨多糖(SIPS)对环磷酰胺(CP)致小鼠肝脏、肾脏、心脏和肺毒性损伤的缓解效果。方法 BALB/c小鼠连续口服给药SIPS(180 mg.kg 1)2周(每天1次),于第6、7天2次腹腔注射CP(100 mg.kg 1)。分别检测肝脏、肾脏、心脏和肺的器官指数和抗氧化能力及肝脏和肾脏的功能参数。结果 SIPS不仅弱化CP所导致的肝脏器官指数的增加(P<0.01),降低CP所致肝脏谷丙转氨酶(P<0.01)与谷草转氨酶(P<0.01)的活力升高,升高CP所致血清中尿素含量的降低(P<0.01),同时不同程度地保护了肝脏(P<0.01)和心脏(P<0.05)的抗氧化能力。结论上述结果表明,SIPS对CP所导致的4种器官毒性损伤具有一定的缓解作用。

Amelioratory Effects of Sepia Ink Polysaccharides on Partial Internal Organs Injuried by Cyclophosphamide

OBJECTIVE To investigate the ameliorative effects of sepia ink polysaccharides (SIPS) on liver, kidney, heart and lung injuried by cyclophosphamide. METHODS BALB/c mice were orally administered with SIPS (180 mg·kg^-1) for two weeks, once a day, and given intraperitoneal injection of cyclophosphamide (100 mg·kg^-1) on the 6th and 7th day during experimental of 14 days. Organ indexes and antioxidant abilities of liver, kidney, lung and heart, as well as functions of liver and kidney were detected. RESULTS SIPS not only significantly impaired the increase of liver index (P<0.01), GPT and GOT activities (P<0.01) and decrease of serum BUN (P<0.01), also obviously protected antioxidant ability of liver (P<0.01) and heart (P<0.05). CONCLUSION The data indicates SIPS alleviate toxicity of CP on the four organs induced by cyclophosphamide.