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| 壬基酚对大鼠甲状腺功能影响的研究 | |
| 引用本文： | 奚悦,李德华,单伟. 壬基酚对大鼠甲状腺功能影响的研究[J]. 天津医药, 2011, 39(9): 835-837,883. DOI: 10.3969/j.issn.0253-9896.2011.09.022 |
| 作者姓名： | 奚悦 李德华 单伟 |
| 作者单位： | 1. 121001,辽宁医学院附属第三医院内分泌与代谢病科 2. 辽宁医学院解剖教研室 |
| 摘 要： | 目的:研究不同剂量壬基酚(NP)对大鼠甲状腺功能的影响。方法:健康4周龄SD大鼠40只,按给NP的剂量分为溶剂对照组(0mg/kg)、低剂量组(40mg/kg)、中剂量组(80mg/kg)和高剂量组(200mg/kg)4组,每组各10只,雌雄各半,造模15d后观察各组组织病理学、组织化学及血清学指标变化。结果:各实验组均可见甲状腺组织增生,4组间琥珀酸脱氢酶(SDH)酶活性差异有统计学意义(P<0.05),血清游离三碘甲状腺原氨酸(FT3)、血清游离甲状腺素(FT4)浓度呈逐渐降低的趋势,促甲状腺素(TSH)浓度呈逐渐升高的趋势,与对照组比较,差异均有统计学意义(P<0.05)。中、高剂量组与低剂量组血清TSH、FT3及FT4比较,差异均有统计学意义(P<0.05),但中、高剂量组间上述指标差异均无统计学意义(P>0.05)。结论:NP可造成甲状腺功能减低。 |
| 关 键 词： | 甲状腺功能试验 琥珀酸脱氢酶 甲状腺素 三碘甲状腺原氨酸 促甲状腺素 壬基酚 大鼠,Sprague-Dawley |
Effects of Nonylphenol on the Structure and Function of the Thyroid Gland in Rats |
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| XI Yue,LI Dehua,AN Wei. Effects of Nonylphenol on the Structure and Function of the Thyroid Gland in Rats[J]. Tianjin Medical Journal, 2011, 39(9): 835-837,883. DOI: 10.3969/j.issn.0253-9896.2011.09.022 | |
| Authors: | XI Yue LI Dehua AN Wei |
| Affiliation: | XI Yue,LI Dehua,SAN WeiThe Third Affiliated Hospital of Liaoning Medical College,Jinzhou 121001,China |
| Abstract: | Objective:To study the effects of different concentrations of nonylphenol(NP) on the structure and function of the thyroid gland in rats.Methods:Forty healthy 4-week-old SD rats were randomly divided into 4 groups,each group comprised of 5 male and 5 female rats.The treated rats were administered different doses of NP(40 mg/kg,80 mg/kg and 200 mg/kg) by pouring stomach.The changes in serum hormones,histopathology and histochemistry results were examined after 15 days of treatment.Results:The hyperplastic th... |
| Keywords: | thyroid function tests succinate dehydrogenase thyroxine triiodothyronine thyrotropin nonylphenol rats Sprague-Dawley |
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