|
|||||
|
|
| Hhcy及B族维生素干预对大鼠脑血管ICAM-1表达的影响 | |
| 引用本文： | 崔磊,张哲成,李新,朱炬,田丽,刘怀翔. Hhcy及B族维生素干预对大鼠脑血管ICAM-1表达的影响[J]. 天津医药, 2011, 39(10): 945-947. DOI: 10.3969/j.issn.0253-9896.2011.10.023 |
| 作者姓名： | 崔磊 张哲成 李新 朱炬 田丽 刘怀翔 |
| 作者单位： | 1. 300170,天津市第三中心医院神经内科 2. 300170,天津医科大学第二医院神经内科 |
| 基金项目： | 天津医科大学科学基金项目(项目编号:2005ky50) |
| 摘 要： | 目的:探讨高同型半胱氨酸血症(Hhcy)及叶酸、维生素B12和维生素B6干预对大鼠脑皮层血管细胞间黏附分子-1(ICAM-1)表达的影响。方法:将40只雄性SD大鼠随机分为对照组、Hhcy组、治疗组和预防组,采用不同饮食结构及干预手段制备动物模型。采用高效液相色谱(HPLC)荧光检测技术测定不同时期各组大鼠血浆总同型半胱氨酸(tHcy)水平,并于第12周末通过免疫组化法观察ICAM-1在大鼠脑皮层血管的表达情况。结果:第4周末大鼠Hhcy模型制备成功,而第12周末对照组、治疗组和预防组血浆tHcy水平差异无统计学意义;预防组大鼠脑皮层ICAM-1阳性血管数与对照组差异无统计学意义,余各组比差异有统计学意义(P<0.05或P<0.01)。结论:Hhcy可以促进大鼠皮层脑血管ICAM-1表达,B族维生素可以有效降低血浆tHcy水平,并且对ICAM-1表达有一定的干预作用。 |
| 关 键 词： | 高同种半胱氨酸血症 干预性研究 胞间黏附分子1 维生素B,复合 大鼠,Sprague-Dawley |
Effect of B Vitamins on the Expression of ICAM-1 in Brain of Rats with Hyperhomocysteinemia |
|
| CUI Lei,ZHANG Zhecheng,LI Xin,ZHU Ju,TIAN Li,LIU Huaixiang. Effect of B Vitamins on the Expression of ICAM-1 in Brain of Rats with Hyperhomocysteinemia[J]. Tianjin Medical Journal, 2011, 39(10): 945-947. DOI: 10.3969/j.issn.0253-9896.2011.10.023 | |
| Authors: | CUI Lei ZHANG Zhecheng LI Xin ZHU Ju TIAN Li LIU Huaixiang |
| Affiliation: | CUI Lei,ZHANG Zhecheng,LI Xin,ZHU Ju,TIAN Li,LIU Huaixiang Department of Neurology,Tianjin Third Central Hospital,Tianjin 300170,China |
| Abstract: | Objective:To observe the effects of hyperhomocysteinemia (Hhcy),folic acid, Vitamin B12 and Vitamin B_6 on the expression of intercellular adhesion molecule 1 (ICAM-1) in the brain of rats with Hhcy. Methods:Forty healthy male Sprague-Dawley rats were divided into 4 groups,control group, Hhcy group, treatment group and prevention. The rat model was established by the way of different foods and different interventions. The plasma levels of total homocysteine (tHcy) were assayed by high-performance liquid chr... |
| Keywords: | hyperhomocysteinemia intervention studies intercellular adhesion molecule-1 vitamin B complex rats Sprague-Dawley |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |
| 点击此处可从《天津医药》浏览原始摘要信息 | |
| 点击此处可从《天津医药》下载免费的PDF全文 | |