Responses of human bone marrow progenitor cells to fluoro-ara-AMP,homoharringtonine, and elliptinium |
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| Authors: | Gunter E Umbach Verena Hug Dr Gary Spitzer Howard Thames Benjamin Drewinko |
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| Institution: | (1) Department of Hematology, The University of Texas M.D. Anderson Hospital and Tumor Institute at Houston, Houston, Texas, USA;(2) Department of Medical Oncology, The University of Texas M.D. Anderson Hospital and Tumor Institute at Houston, Houston, Texas, USA;(3) Department of Biomathematics, The University of Texas M.D. Anderson Hospital and Tumor Institute at Houston, Houston, Texas, USA;(4) Department of Laboratory Medicine, The University of Texas M.D. Anderson Hospital and Tumor Institute at Houston, Houston, Texas, USA;(5) Department of Hematology, The University of Texas M.D. Anderson Hospital and Tumor Institute at Houston, 6723 Bertner Avenue, 77030 Houston, TX, USA |
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| Abstract: | Summary The cytotoxicity of the investigational anticancer drugs fluoro-ara-AMP, homoharringtonine, and elliptinium on normal human granulocyte-macrophage colony-forming units in culture (GM-CFU) was investigated using a bilayer soft agar system. For each drug, the dose-dependent survival curve on a semilogarithmic plot formed a straight line. The Do were: 0.51  g/ml (fluoro-ara-AMP), 0.004 g/ml (homoharringtonine) and 0.026 g/ml (elliptinium). The in vitro toxicity of drugs on bone marrow progenitor cells did not correlate with the relative myelosuppressive potency observed in vivo. |
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| Keywords: | human bone marrow fluoro-ara-AMP homoharringtonine elliptinium |
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