慢性肺心病急性发作期肺动脉高压治疗方法的系统研究

该研究系统观察了92例慢性肺心病急性发作期患使用4类6种血管扩张药物，其中包括硝普钠、氨力农、米力农、维拉帕米、地尔硫zhuo、卡托普剂，以及吸入低浓度一氧化氮和施行机械通气两种方式的治疗效果。并各自比较使用前后其血流动力学及氧动力学变化。观察结果表明，上述药物及方法均可有效地降低肺动脉压力、阻力，有良好的急性血流动力学效应及氧动力学效应。同时还分析了上述各种降压药物的作用特点和相应临床应用特征，对选择临床治疗方法有指导意义。

The Methodological Research on Effective Reduction of Pulmonary Hypertension in COPD Patients

Responses have been observed and compared in 92 patients at acute episode of chronic pulmonary heart disease caused by chronic obstructive pulmonary disease (COPD). The patients were given one of 6 vasodilators including sodium nitroprusside, amrinone, milrinone, verapamil, diltiazem and captopril, the inhalation of NO and -mechanical ventilation respectively. The changes in patients' hemodynamics and oxygen - dynamics prior to and after each treatment have showed that the above - mentioned regimens reduced the pulmonary arterial pressure and resistance effectively, and had good acute hemodynamic and oxygen - dynamic effects. The characteristics and the indications of these, vasodilators were also evaluated, which might be valuable for the selection of vasodilator in clinical practice .