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| 环孢菌素A对三种淋巴因子生物活性及其基因表达的影响 | |
| 引用本文： | 蔡年生 Cheu.,HT. 环孢菌素A对三种淋巴因子生物活性及其基因表达的影响[J]. 中国抗生素杂志, 1990, 15(4): 243-248 |
| 作者姓名： | 蔡年生 Cheu. HT |
| 作者单位： | 中国医学科学院医药生物技术研究所，中国医学科学院医药生物技术研究所，Departments of chemistry and Biological Sciences Illinois State University，Departments of chemistry and Biological Sciences Illinois State University 北京 100050，北京 100050，Normal.IL 61761，Normal.IL 61761 |
| 摘 要： | 环孢菌素A抑制了用ConA和PMA在体外诱导小鼠脾淋巴细胞分泌的白细胞介素2、白细胞介素3和粒细胞巨噬细胞集落刺激因子,这种抑制作用与这些淋巴因子的信使核糖核酸的基因表述受到抑制有关。 |
| 关 键 词： | 环孢霉素 淋巴因子 基因表达 |
EFFECT OF CYCLOSPORJN A ON THE PRODUCTION OF THREE LYMPHOKINES AND THE EXPRESSION OF THEIR mRNAs IN MICE |
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| Cai Nian-sheng,Li Dian-dong,H. Tak Cheung and Arlan Richardson. EFFECT OF CYCLOSPORJN A ON THE PRODUCTION OF THREE LYMPHOKINES AND THE EXPRESSION OF THEIR mRNAs IN MICE[J]. Chinese Journal of Antibiotics, 1990, 15(4): 243-248 | |
| Authors: | Cai Nian-sheng Li Dian-dong H. Tak Cheung Arlan Richardson |
| Abstract: | CyclosporinA (CyA) inhibit the induction of interleukin 2 (IL 2 ) , interleukin 3 (IL 3) and granulocyte-macrophage colony stimulating factor (GM-CSF) secretion by Con A and phorbol myristate acetate (PMA) induced spleen lymphocytes. The lack of these lymphokines correlates with the absence of their respective mRNAs. Lymphokines in general and IL2,IL3, GMCSF in particular play a central role in immune responses, Thus, the ability of CyA to prevent lymphokine gene expression, at concentration use therapeutically, may in explain the immuno-suppressive properties of this class of drugs. |
| Keywords: | Cyclosporin A(CyA) Interleukin 2(IL2) Interleukin 3 (IL 3 ) Granulocyte-macrophage colony Stimulating factor (GMCSF) |
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