左乙拉西坦与托吡酯对儿童癫痫的疗效比较

目的：研究比较左乙拉西坦（LEV）和托吡酯（TPM）对儿童癫痫单药治疗的疗效及安全性。方法：纳入2007-01～2009-06收治的儿童癫痫患者45例,随机分组为左乙拉西坦治疗组（A组）20例,托吡酯治疗组（B组）25例。治疗剂量：A组初始剂量25mg/d,每周增加25mg,目标量为6～8mg/（d.kg）,在6～7周内达到目标剂量。B组起始剂量为0.5～1.0mg/（d.kg）,根据病情每周增加0.5～1.0mg/（d.kg）,最终维持剂量为4～6mg/（d.kg）。随访3～12个月。结果：A组左乙拉西坦单药治疗的总有效率为85%,B组托吡酯单药治疗的总有效率为88%。结论：左乙拉西坦和托吡酯对于儿童癫痫的单药治疗是安全有效的。

Efficacy Compared of Levetiracetam and Topiramate Monotherapy on Children with Epilepsy

Objective：To compare levetiracetam （LEV） and topiramate （TPM） monotherapy for epilepsy in children the efficacy and safety. Methods：Included from January 2007 to June 2009 for children with epilepsy treated 45 patients randomized to levetiracetam treatment group （A group） 20 cases of topiramate treatment group （B group） 25 cases. Therapeutic dose：A group of the initial dose of 25 mg/d,a weekly increase of 25 mg,target volume of 6 ～ 8 mg/（d.kg）,in 6 ～ 7 weeks to achieve the target dose. Group B starting dose of 0. 5 ～ 1. 0 mg/（d.kg）,according to the disease each week to increase 0. 5 ～ 1. 0 mg/（d.kg）,the final maintenance dose of 4 ～ 6 mg/（d.kg）. Follow -up of 3 ～ 12 months. Results：A group of levetiracetam monotherapy for a total effective rate was 85% ,B group of topiramate monotherapy in total effective rate was 88%. Conclusions：Levetiracetam and topiramate monotherapy for the treatment of epilepsy in children is safe and effective.