Restriction endonuclease map of endogenous mouse mammary tumor virus loci in GR, DBA, and NFS mice |
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| Authors: | D A Gray E C Chan J I MacInnes V L Morris |
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| Affiliation: | 1. Department of Microbiology and Immunology, University of Western Ontario, London, Ontario N6A 50, Canada;2. Department of Veterinary Microbiology and Immunology, University of Guelph, Guelph, Ontario NiG 2W1, Canada;1. Department of Tropical Viral Vaccine Development, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan;2. Department of Virology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan;3. Center for Vaccines and Therapeutic Antibodies for Emerging Infectious Diseases, Shimane University, Izumo, Japan;4. Centre for Clinical Management of Dengue & Dengue Haemorrhagic Fever, District General Hospital, Negombo 11500, Sri Lanka;5. Molecular Medicine Unit, Faculty of Medicine, University of Kelaniya, Ragama 11010, Sri Lanka;6. Kenya Research Station, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan;7. Department of Virology, National Hospital Kandy, Kandy 20000, Sri Lanka;8. DEJIMA Infectious Disease Research Alliance, Nagasaki University, Nagasaki 852-8523, Japan |
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| Abstract: | ![]()
Mouse mammary tumor virus (MMTV) is integrated in the genome of most mice as an endogenous provirus. Two of these MMTV proviral loci (Mtv-1 and Mtv-2) are associated with virus expression and tumorigenicity. We prepared restriction endonuclease maps of the endogenous MMTV proviruses in two strains, DBA and GR, which contain the Mtv-1 and Mtv-2 loci, plus a third strain, NFS, which has a low mammary tumor incidence. We find that all these mouse strains have certain MMTV loci in common even though their origins are widely divergent. We also find that some integrated MMTV proviruses appear to have undergone alterations or deletions when compared with MMTV exogenous proviral DNA. We have thus made a comprehensive characterization of MMTV loci in these mouse strains which could serve as a basis for the study of their differences in expression. |
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