联用消心痛和参麦注射液治疗慢性阻塞性肺疾病急性加重期合并心肌损害的疗效观察

目的 :观察联用消心痛和参麦注射液在治疗慢性阻塞性肺疾病 (COPD)急性加重期合并心肌损害的疗效。方法 :将 1999年 4月— 2 0 0 3年 4月收治的 6 3例 COPD急性加重期 (AECOPD)合并心肌损害患者随机分为对照组 (按常规治疗 )及观察组 (联用消心痛和参麦注射液 7～ 10 d) ,比较两组症状、体征、心电图和心肌酶学恢复时间。结果 :观察组主要症状、体征的改善时间及心率、心电图、心肌酶的恢复时间均较对照组显著缩短(P均 <0 .0 1) ,观察组显效率 5 3.3% (16 /30 )和总有效率 80 .0 % (2 4 /30 )也均明显高于对照组〔分别为 2 1.2 %(7/33)和 5 4 .5 % (18/33) ,P<0 .0 5和 P<0 .0 1〕。结论 :联用消心痛和参麦注射液对 AECOPD合并心脏损害患者疗效满意

Effects of isorsorbide dinitrate combined with Shenmai injection(参麦注射液) on acute exacerbation of chronic obstructive pulmonary disease accompaning myocardial injury

Objective: To observe the therapeutic effect of isorsorbide dinitrate combined with Shenmai injection in treatment for acute exacerbation of chronic obstructive pulmonary disease(AECOPD) and myocardial injury. Methods: Sixty-three patients with AECOPD admitted from April 1999 to April 2003 were randomly divided into two groups: isorsorbide and Shenmai injection therapeutic(7- 10 days ) group (treatment group, n =30) and conventional therapy group (control group, n =33). Recovery time of patients' symptom, sign, electrocardiogram and myocardial enzyme were observed. Results: The markedly effective rate (53 3 percent) and total effective rate (80 0 percent) were higher in the treatment group than those in the control group (21 2 percent and 54 5%), P <0 01 or P <0 05. Compared with the control group, the treatment group had shorter recovery time of heart rate, electrocardiogram, myocardial enzyme and for the disappearance of symptoms and signs. Conclusion: Treatment of AECOPD accompaning myocardial injury with isorsorbide dinitrate combined with Shenmai injection shows satisfactory clinical effects.