Generation of reactive oxygen species by mitochondria in senescence-accelerated OXYS rats |
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| Authors: | Men'shchikova E B Shabalina I G Zenkov N K Kolosova N G |
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| Affiliation: | (1) Research Center for Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Russia;(2) Institute of Biochemistry, Siberian Division of the Russian Academy of Medical Sciences, Russia;(3) Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk |
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| Abstract: | ![]()
Chemiluminescence assay showed that oxygen reduction and production of superoxide anion and hydrogen peroxide by liver mitochondria in OXYS rats highly sensitive to oxidative stress were less intensive than in Wistar rats. Experiments with cytochrome c oxidase inhibitors showed that decreased O2- generation in mitochondria of OXYS rats is probably associated with changes in complex III of the electron transport chain. |
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| Keywords: | OXYS rats reactive oxygen species mitochondria |
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